|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The possible mechanisms of the synergistic efficacy are: (1) sunitinib caused upregulation of CAIX in tumor cells; (2) sunitinib decreased frequency of myeloid-derived suppressor cells in the tumor microenvironment.
|
31574023 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Carbonic Anhydrase IX-Targeted Near-Infrared Dye for Fluorescence Imaging of Hypoxic Tumors.
|
30185025 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, CA-IX expression was found in 15% of IDH-mutated and in 7.7% of IDH-nonmutated tumors (P = 0.484).
|
21643985 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, targeted nanobubbles carrying CAIX polypeptides for targeted binding to a variety of malignant tumors were constructed, and targeted binding ability and ultrasound imaging effect in different types of tumors were evaluated.
|
28962657 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Interestingly, CAIX was overexpressed in the tumor initiating cell population.
|
26152355 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Generalized up-regulation of CA IX in VHL-associated renal cell carcinoma contrasted with focal perinecrotic expression in a variety of non-VHL-associated tumors.
|
11156414 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of carbonic anhydrase IX (CAIX) and loss of AT-rich interactive domain-containing protein 1A (ARID1A), aldehyde dehydrogenase 1 (ALDH1), and CD44 expression in GA patients were significantly correlated with lymph node (LN) metastasis, advanced tumor stage, and poor prognosis.
|
27910777 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In cancer, CAIX expression is associated with tumor hypoxia.
|
25434612 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Novel CAIX inhibitors have shown efficacy in both <i>in vitro</i> and <i>in vivo</i> pre-clinical cancer models, adversely affecting cell viability, tumour formation, migration, invasion, and metastatic growth when used alone.
|
29439394 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Saccharin known to act as carbonic anhydrase IX (CA IX) inhibitor which is a biomarker for highly aggressive and proliferative tumor in hypoxic stress, so inhibition of CA IX is a potential strategy for anticancer chemotherapy.
|
28482217 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of hypoxia-associated proteins was in most cases identical between primary tumours and lymph node metastases.Two cases showed strong uniform expression of CAIX and HIF1α in the primary tumour as well as in the lymph node metastases, and sequencing revealed mutations in the coding regions of the Von-Hippel–Lindau gene (VHL ).Our findings suggest that despite of the fact that MTCs have only slowly growth, tumour hypoxia plays an important role in the development of loco-regional metastases.
|
21630273 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NHE1-ko significantly reduced tumor cell proliferation both in normoxia and hypoxia while CA9-ko dramatically reduced growth in hypoxic conditions.
|
28055960 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
At immunohistochemistry, the clear cells in both tumors were positive for CD10 and CA IX.
|
26874573 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
There was no relationship between HPV status and tumor pO(2) or CAIX staining.
|
19427557 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Between 2006 and 2011, 79 patients with CA9-positive and 37 with CA9-negative tumors were enrolled, respectively.
|
27102843 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Works on tissues suggested the potential use of CAIX as a tumor biomarker for urogenital malignancies, but only few studies have been performed on its detection in urine.
|
27005925 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Endocervical glandular neoplasia associated with lobular endocervical glandular hyperplasia is HPV-independent and correlates with carbonic anhydrase-IX expression: a Gynaecological Oncology Group Study.
|
23299542 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, we found that carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion, and then identified dickkopf-1 (DKK-1) as a novel CA9-interacting protein.
|
22430125 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CAIX expression decreased with increasing tumor stage and grade.
|
26138037 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
One feature of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor growth.
|
27197160 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These preclinical data collectively support the development of BAY 79-4620 for the treatment of cancer patients with CAIX overexpressing tumors.
|
22147747 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.
|
29962205 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor specimens were analyzed by immunohistochemistry (IHC) for phosphorylated AKT (pAKT), glucose transporter type 1 (GLUT-1), carbonic anhydrase IX (CA IX), podoplanin-positive cancer associated fibroblasts (PDPN + CAFs), and CD204-positive tumor-associated macrophages (CD204+ TAMs).
|
31445355 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Study of tumors from patients treated with interleukin-2 (IL-2) has suggested that response was unlikely in patients with tumors with papillary features or low carbonic anhydrase IX (CAIX) expression.
|
19402069 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results show CAIX to be an essential part of the tumour microenvironment and a possible master regulator of tumour progression.
|
29865880 |
2018 |