ZNF141, zinc finger protein 141, 7700

N. diseases: 8; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3808889
Disease: POLYDACTYLY, POSTAXIAL, TYPE A6
POLYDACTYLY, POSTAXIAL, TYPE A6 		0.600 GeneticVariation disease UNIPROT Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A. 23160277 2013
CUI: C3808889
Disease: POLYDACTYLY, POSTAXIAL, TYPE A6
POLYDACTYLY, POSTAXIAL, TYPE A6 		0.600 Biomarker disease GENOMICS_ENGLAND Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A. 23160277 2013
CUI: C3808889
Disease: POLYDACTYLY, POSTAXIAL, TYPE A6
POLYDACTYLY, POSTAXIAL, TYPE A6 		0.600 GeneticVariation disease CLINVAR Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A. 23160277 2013
CUI: C3808889
Disease: POLYDACTYLY, POSTAXIAL, TYPE A6
POLYDACTYLY, POSTAXIAL, TYPE A6 		0.600 CausalMutation disease CLINVAR
CUI: C3887487
Disease: Postaxial polydactyly type A
Postaxial polydactyly type A 		0.310 GermlineCausalMutation disease ORPHANET Nosology and classification of genetic skeletal disorders: 2015 revision. 26394607 2015
CUI: C3887487
Disease: Postaxial polydactyly type A
Postaxial polydactyly type A 		0.310 GermlineCausalMutation disease ORPHANET Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A. 23160277 2013
CUI: C3887487
Disease: Postaxial polydactyly type A
Postaxial polydactyly type A 		0.310 GeneticVariation disease BEFREE Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A. 23160277 2013
CUI: C0152427
Disease: Polydactyly
Polydactyly 		0.300 Biomarker disease GENOMICS_ENGLAND Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A. 23160277 2013
CUI: C0431904
Disease: Ulnar polydactyly of fingers
Ulnar polydactyly of fingers 		0.100 Biomarker disease HPO
CUI: C4024412
Disease: Broad phalanges of the 5th finger
Broad phalanges of the 5th finger 		0.100 Biomarker disease HPO
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.060 Biomarker disease BEFREE Allelic frequencies of RFLPs at loci closely linked to the HD gene, D4S95, D4S91, D4S141, and D4S90, were determined in 13 Huntington's disease (HD) patients from nine Chinese families and 129 normal subjects. 7760321 1995
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.060 Biomarker disease BEFREE To explain these results, it was suggested that the HD locus (HD) lies close to the telomere and that a recombination event took place between HD and the most telomeric marker examined, D4S90. 1350884 1992
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.060 GeneticVariation disease BEFREE Twelve Italian families with Huntington disease were tested with 10 probes known to be linked to the disease locus and able to detect polymorphisms at the following loci on chromosome 4: D4S10, D4S127, D4S95, D4S43, D4S115, D4S111, D4S90. 1829583 1991
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.060 Biomarker disease BEFREE D4S95 is a most useful DNA marker for predictive testing programs, while D4S90 will serve as a useful starting point for identifying DNA fragments closer to the gene for HD. 2521771 1989
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.060 Biomarker disease BEFREE A new DNA marker (D4S90) is located terminally on the short arm of chromosome 4, close to the Huntington disease gene. 2574148 1989
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.060 Biomarker disease BEFREE These data suggest that it may be possible to construct high and low risk haplotypes, which may be helpful in DNA analysis and genetic counselling for HD, and represent independent evidence that the gene for HD is centromeric to more distally located DNA markers such as D4S90. 2531224 1989
CUI: C0220697
Disease: POLYDACTYLY, POSTAXIAL
POLYDACTYLY, POSTAXIAL 		0.010 GeneticVariation disease BEFREE This study revealed involvement of a zinc finger gene ZNF141 in causing autosomal recessive PAP type A, which may open up interesting perspectives into the function of this protein in limb development. 23160277 2013
CUI: C1956097
Disease: Wolf-Hirschhorn Syndrome
Wolf-Hirschhorn Syndrome 		0.010 Biomarker disease BEFREE ZNF141 mapped to the distal end of the 2.2 Mb smallest region of deletion overlap of WHS, 300 kb from the 4p telomere on cosmid CD1 defining the anonymous locus D4S90. 8268908 1993