|
Liver carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
We found that miR-6875-3p were elevated expressed in HCC tissues and cell lines, and negatively correlated with BTG2 expression, while positively correlated with tumor staging, size, degree of differentiation, and vascular invasion of HCC.
|
30621734 |
2019 |
|
Liver carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Ectopic BTG2 overexpression decreased HCC growth, caused cell cycle arrest at the G1 phase, and downregulated Cyclin D1 and Cyclin E1 protein expression.
|
29441724 |
2018 |
|
Liver carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
In vitro, overexpression of BTG2 substantially suppressed cell proliferation and accumulation of HCC cell line SP cells in G0/G1 phase.
|
29098552 |
2017 |
|
Liver carcinoma
|
0.380 |
Biomarker
|
disease |
BEFREE |
Future studies would confirm the role of BTG2 in hepatoma, and further develop BTG2 as a therapeutic strategy for controlling HCC.
|
28454405 |
2017 |
|
Liver carcinoma
|
0.380 |
Biomarker
|
disease |
BEFREE |
The results of the present study may provide a basis for targeting the miR‑21/BTG2 interaction for the treatment of HCC.
|
26151427 |
2015 |
|
Liver carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
BTG2 mRNA was expressed in 71.19% HCC by ISH and correlated with differentiation.
|
21327578 |
2011 |
|
Liver carcinoma
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
PC3/BTG2 mRNA was located mainly in the cytoplasm of HCC cells and its expression was related to the degree of differentiation.
|
19502170 |
2009 |
|
Liver carcinoma
|
0.380 |
Biomarker
|
disease |
BEFREE |
These observations were further confirmed in vivo by the reciprocal control of TIS21 expression and FoxM1 phosphorylation in the diethylnitrosamine-induced HCCs and TIS21(-/-) mouse embryonic fibroblast (MEF), in addition to increased expression of cyclin B1 and cdk1 activity.
|
18393292 |
2008 |
|
Liver carcinoma
|
0.380 |
Biomarker
|
disease |
CTD_human |
These observations were further confirmed in vivo by the reciprocal control of TIS21 expression and FoxM1 phosphorylation in the diethylnitrosamine-induced HCCs and TIS21(-/-) mouse embryonic fibroblast (MEF), in addition to increased expression of cyclin B1 and cdk1 activity.
|
18393292 |
2008 |
|
Chloracne
|
0.300 |
Biomarker
|
disease |
CTD_human |
Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects.
|
17101203 |
2007 |
|
Spinal Cord Ischemia
|
0.200 |
Biomarker
|
disease |
RGD |
Mediators of ischemic preconditioning identified by microarray analysis of rat spinal cord.
|
14697320 |
2004 |
|
Myocardial Reperfusion Injury
|
0.200 |
Biomarker
|
phenotype |
RGD |
Brief episode of ischemia activates protective genetic program in rat heart: a gene chip study.
|
12909328 |
2003 |
|
Reperfusion Injury
|
0.200 |
Biomarker
|
disease |
RGD |
Overexpression of the PC3/TIS21/BTG2 mRNA is part of the stress response induced by acute pancreatitis in rats.
|
9712737 |
1998 |
|
Pancreatitis, Acute Necrotizing
|
0.200 |
Biomarker
|
disease |
RGD |
Overexpression of the PC3/TIS21/BTG2 mRNA is part of the stress response induced by acute pancreatitis in rats.
|
9712737 |
1998 |
|
Brain Ischemia
|
0.200 |
Biomarker
|
disease |
RGD |
Immediate early gene induction after neonatal hypoxia-ischemia.
|
7684483 |
1993 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Collectively, our results indicate that the HP1BP3-BTG2 axis constitutes a fail-safe system to prevent oncogenesis by means of OIS induction, and that this system is hijacked by ST.
|
31819167 |
2020 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
(6) mRNAs and protein expressions of elongation factors were also downregulated by BTG2<sup>/TIS21</sup> expression in TNBC cells, but much higher in both TIS21-KO mice and lymph node-positive human breast cancers.
|
31138781 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Btg2 mRNA expression was lower in GH3 tumors compared to the parental line, and DAPT increased its expression levels in the tumor in parallel with the inhibition of its volume.
|
30121620 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found that miR-6875-3p were elevated expressed in HCC tissues and cell lines, and negatively correlated with BTG2 expression, while positively correlated with tumor staging, size, degree of differentiation, and vascular invasion of HCC.
|
30621734 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nkx2-2as functioned as a competing endogenous RNA against miR-103 and miR-107, sequestering them and thereby derepressing their tumor suppressive targets BTG2 and LATS1 and impeding cell division and migration.
|
29229597 |
2018 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Three CpG probes (cg01798157, cg06373167, cg23371584) that detected BTG2 hypermethylation in tumour tissues were associated with lower overall survival.
|
29656435 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, tumor (PC-3) targeting for [<sup>68</sup>Ga]3 and [<sup>68</sup>Ga]4 increased over time, with dynamic μPET showing clearer tumors images at later time points.
|
29432691 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall the results suggest that Tis21-gene therapy slows down MB tumor growth through inhibition of proliferation and enhancement of neural differentiation.
|
29538458 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The TIS21<sup>/BTG2/PC3</sup> gene belongs to the antiproliferative gene (APRO) family and exhibits tumor suppressive activity.
|
29385670 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results suggested that BTG2 functioned as a bladder cancer tumor suppressor gene, and was induced by p53 and PTEN.
|
29239139 |
2018 |