CXCR4, C-X-C motif chemokine receptor 4, 7852

N. diseases: 739; N. variants: 23
Disease: Lymphopenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024312
Disease: Lymphopenia
Lymphopenia 		0.120 Biomarker disease BEFREE Therefore, efficient Cxcr4 desensitization is critical for lymphoid differentiation of HSPCs, and its impairment is a key mechanism underpinning the lymphopenia observed in mice and likely in WS patients. 28550161 2017
CUI: C0024312
Disease: Lymphopenia
Lymphopenia 		0.120 Biomarker disease BEFREE In contrast, Cxcr4(+/1013) mice show defective thymopoiesis and B-cell development, accounting for circulating lymphopenia. 22438253 2012
CUI: C0024312
Disease: Lymphopenia
Lymphopenia 		0.120 Biomarker disease HPO