Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mRNA level of stromal cell-derived factor-1 (SDF-1) in the lung and the number of accumulated SDF-1-expressing CD11b<sup>+</sup>Gr1<sup>+</sup> MDSCs were elevated at an early stage in lung metastasis of C-X-C chemokine receptor type 4 (CXCR4)-expressing RM9 in an mPGES-1-dependent manner.
|
31715374 |
2020 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
LRP6N prevented SDF-1/CXCR4-induced metastasis to lung and prolonged survival in mice bearing breast tumors, whereas LRP6 knockdown activated SDF-1/CXCR4 signal transduction and promoted lung metastasis and tumor death.
|
31010839 |
2019 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we propose a novel therapeutic approach based on anti-CXCR4 blocking antibody in combination with NKAE cell therapy to prevent rhabdomyosarcoma tumor implantation and lung metastasis.
|
31428099 |
2019 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
As a corollary, a reduction in CXCR4 dependent lung metastasis was detected.
|
31332163 |
2019 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, the Mg and Ex-Mg-1Ag-1Y alloy, both demonstrated resisting effects against local tumor growth and pulmonary metastasis, which could be performed by changing the extracellular acidosis microenvironment, elevating the Mg concentration, suppressing C-X-C chemokine receptor type 4 (CXCR4) levels, and increasing prostacyclin (PGI<sub>2</sub> ) synthesis.
|
30779430 |
2019 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data indicated that CXCR4 mediated osteosarcoma cell growth and lung metastases and this effect can be suppressed by miR-613 through directly downregulating CXCR4.
|
29845707 |
2018 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Repeated T22-GFP-H6-FdU administration in cell line and patient-derived CRC models blocks intravasation and completely prevents metastases development in 38-83% of mice, while showing CXCR4 expression-dependent and site-dependent reduction in foci number and size in liver, peritoneal, or lung metastases in the rest of mice, compared to free oligo-FdU.
|
30190334 |
2018 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using tumor tissue microarrays, we analyzed the expression of CXCR4 and MMP9 among 34 primary osteosarcomas with pulmonary metastasis and 62 primary osteosarcomas without metastasis.
|
26546437 |
2016 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Additionally, IL-24, when combined with CXCR4 inhibitors exhibited enhanced anti-metastatic activity and is an attractive therapeutic strategy for lung metastasis.
|
25775124 |
2015 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Silencing of CXCR4 was associated with a decrease in the tumorigenic properties of MDA-MB-231 breast cancer cells, caused reversion of EMT and suppression of MMP-9, increased apoptosis, and caused a reduced incidence of tumor lung metastasis in mice.
|
24256053 |
2014 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study reveals the highly plastic and dynamic nature of CXCR4 expression in Ewing sarcoma and supports a model in which stress-induced upregulation of CXCR4 contributes to tumor metastasis to lung and bone marrow, which express high levels of SDF-1a.
|
24651452 |
2014 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Blockade of CXCR4 and iNOS was suggested to inhibit lung metastases from ACCIM.
|
23835861 |
2013 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of the chemokine receptor CXCR7 in CXCR4-expressing human 143B osteosarcoma cells enhances lung metastasis of intratibial xenografts in SCID mice.
|
24040160 |
2013 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
In xenograft studies, CXCR4-enriched cells formed large tumors and exhibited significantly elevated lung metastasis.
|
20603605 |
2010 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases.
|
17041104 |
2006 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
CXCR4, but not CCR7, expression dramatically increased the in vivo metastatic potential of TD-2 cells, resulting in liver and lung metastasis in nude mice.
|
16230077 |
2005 |