|
Malignant Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
The expression of m6A methylases (METTL3, METTL14 and WTAP) and demethylases (FTO and ALKBH5) were analyzed by using ONCOMINE and The Cancer Genome Atlas databases and in 36 pairs of BC and adjacent non-cancerous tissue.
|
30953473 |
2019 |
|
Malignant Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Although RNA methyltransferase inhibitors are not available yet, FTO inhibitors have shown promising anticancer effects <i>in vitro</i> and in animal models of cancer.
|
30894375 |
2019 |
|
Malignant Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
Mounting evidence indicated that FTO plays a critical role in occurrence, progression and treatment of various cancers, even acting as a cancer oncogene in acute myeloid leukaemia, research on which is no longer restricted to metabolic diseases such as obesity and diabetes.
|
30465076 |
2019 |
|
Malignant Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
This mini review discusses the roles and underlying molecular mechanisms of FTO in both obesity and cancers, and also summarizes recent advances in the development of FTO inhibitors.
|
30105001 |
2018 |
|
Malignant Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The rs9939609 polymorphism in the FTO gene has recently been implicated as a risk factor for some types of cancer, such as breast, pancreatic, and prostate cancers.
|
29260910 |
2018 |
|
Malignant Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Previous studies have examined the association between the fat mass and obesity-associated (<i>FTO</i>) gene variant and risk of cancer in diverse populations.
|
28881622 |
2017 |
|
Malignant Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Association between FTO gene polymorphism (rs9939609 T/A) and cancer risk: a meta-analysis.
|
26931363 |
2017 |
|
Malignant Neoplasms
|
0.200 |
Biomarker
|
group |
BEFREE |
It has been reported previously that FTO is associated with a variety of malignant cancers, such as breast, thyroid and endometrial cancer.
|
28849183 |
2017 |
|
Malignant Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Participants from the Tübingen Family study (n = 2245) and the Malmö Diet and Cancer study (n = 2921) were genotyped for FTO SNP rs8050136 and ANKK1 SNP rs1800497.
|
27600277 |
2016 |
|
Malignant Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Recently, several studies have reported associations between fat mass and obesity-associated (FTO) gene mutations and cancer susceptibility.
|
26146447 |
2015 |
|
Malignant Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
However, it is now unquestionable that certain FTO polymorphisms regulate genetic expression related to cancer susceptibility, although this field is just beginning to be understood.
|
25387436 |
2015 |
|
Malignant Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The homocysteine level was not associated with either MTHFR C677T or A1298C, nor with FTO rs1477196, but was inversely correlated with folate status in cancer cases (p<0.0001) and tended to be higher in patients with the MTHFR 677TT genotype.
|
24023349 |
2013 |
|
Malignant Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The results suggested that FTO rs9939609 polymorphism was not significantly associated with the increased risk of cancer (OR = 1.01, 95 %CI 0.98-1.04), with the exception that a statistically significant association was found for pancreatic cancer (OR = 1.10, 95 %CI 1.03-1.19).
|
22396042 |
2012 |
|
Malignant Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Among 22,799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up.
|
21179003 |
2011 |
|
Malignant Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The FTO variant rs1121980 was genotyped in 20,374 participants (39-79 y of age) from the European Prospective Investigation into Cancer and Nutrition-Norfolk Study, an ethnically homogeneous population-based cohort.
|
19553294 |
2009 |
|
Malignant Neoplasms
|
0.200 |
GeneticVariation
|
group |
BEFREE |
To avoid these biases we used a Mendelian randomization approach incorporating an analysis of variants in the FTO gene that are strongly associated with BMI levels among 7000 subjects from a study of lung, kidney and upper-aerodigestive cancer.
|
19542184 |
2009 |