|
Metabolic Syndrome X
|
0.200 |
Biomarker
|
disease |
BEFREE |
Relationship Between Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms with Obesity and Metabolic Syndrome in Ethnic Mongolians.
|
30442880 |
2018 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that ALE supplementation may improve serum triglyceride level in A allele genotype of FTO-rs9939609 polymorphism in women with MetS.
|
29193419 |
2018 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to investigate whether the FTO gene polymorphisms are associated with the risk of MetS and its simple components in a homogeneous sample of males.
|
30091536 |
2018 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mechanisms of metabolic syndrome (MetS) causation are complex, genetic and environmental factors are important factors for the pathogenesis of MetS In this study, we aimed to evaluate familial and genetic influences on metabolic syndrome risk factor and also assess association between FTO (rs1558902 and rs7202116) and CETP(rs1864163) genes' single nucleotide polymorphisms (SNP) with low HDL_C in the Tehran Lipid and Glucose Study (TLGS).
|
29548861 |
2018 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, polymorphisms in the FTO gene were associated with increased obesity risk, whereas polymorphisms in the FTO and FABP2 genes were also associated with the risk of developing MS in general unmatched cohorts.
|
28738793 |
2017 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The present study shows for first time that FTO gene rs9939609 is genetic risk factor for metabolic syndrome in Egyptian population which may help in understanding the biology of this complex syndrome and highlighted that this association may be through HDL-C component.
|
28915859 |
2017 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of genetic variants in the FTO gene with metabolic syndrome: A case-control study in the Tunisian population.
|
26700404 |
2016 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
DNA was extracted from the whole blood of 192 natural postmenopausal women (40 to 65 years) screened for the METS and tested for three gene SNPs related to obesity: the fat mass obesity (FTO: rs9939609) and the methylenetetrahydrofolate reductase (MTHFR: C677T and A1298C).
|
26902996 |
2016 |
|
Metabolic Syndrome X
|
0.200 |
Biomarker
|
disease |
BEFREE |
The FTO gene in Turkish adults contributes independently to obesity in women and-by interacting with BMI-to MetS and insulin resistance in men.
|
27146691 |
2016 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study aims to assess the association of the rs9939609 variant and haplotypes in FTO gene with metabolic syndrome (MetS) components in a Tunisian population sample.
|
26741700 |
2016 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Age and physical activity modulated the effect of the FTO polymorphism on weight status and metabolic syndrome in Lithuanian adult population.
|
27003669 |
2016 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Several genes showed strong evidence for an association with MetS in patients with schizophrenia, including the fat mass and obesity associated gene (FTO), leptin and leptin receptor genes (LEP, LEPR), methylenetetrahydrofolate reductase (MTHFR) gene and the serotonin receptor 2C gene (HTR2C).
|
26621002 |
2016 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association between polymorphisms of fat mass and obesity-associated gene and metabolic syndrome in Kazakh adults of Xinjiang, China.
|
26600519 |
2015 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The Fat Mass and Obesity-Associated Protein (FTO) gene rs9939609 single nucleotide polymorphism (SNP) has been associated with obesity, metabolic syndrome, insulin resistance (IR), and type 2 diabetes mellitus in the general population.
|
25367448 |
2014 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the FTO, LEPR and MTHFR genes may play a role in MS in Malaysian schizophrenia patients receiving long-term treatment with APs.
|
24624915 |
2014 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the FTO rs9939609 genotype accounted for 21.3% of the MetS phenotype together with total cholesterol, BMR and age.
|
24675148 |
2014 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to analyze the relationship of the rs9939609 FTO gene polymorphism with metabolic syndrome and its components.
|
23490278 |
2014 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, FTO rs9939609 was associated with obesity measures, especially in those with the MetS, which was further exacerbated by high dietary SFA intake at baseline and 7.5 y later.
|
22457394 |
2012 |
|
Metabolic Syndrome X
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, we concluded that the FTO gene may play a critical role in leading to MetS.
|
22189543 |
2012 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The C allele of the rs7204609 polymorphism in the FTO gene increased the chance for the presence of MetS, especially central obesity, and microalbuminuria, independently of energy and nutrient intakes in this sample of type 2 diabetic patients from Southern Brazil.
|
21741858 |
2012 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mechanistic investigation is also needed to clarify the effect of FTO gene in the predisposition to MetS.
|
22311015 |
2012 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome.
|
21796137 |
2011 |
|
Metabolic Syndrome X
|
0.200 |
Biomarker
|
disease |
BEFREE |
No significant associations were found between our FTO SNPs and any endophenotypes of MetS.
|
20819567 |
2010 |
|
Metabolic Syndrome X
|
0.200 |
Biomarker
|
disease |
BEFREE |
These data confirm the influential role of the FTO gene in obesity in the French female population and, in addition, revealed the role of FTO in insulin resistance and MetS.
|
19818665 |
2009 |
|
Metabolic Syndrome X
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
FTO genotype was associated with a higher odds of metabolic syndrome (odds ratio 1.17 [95% CI 1.10-1.25]; P = 3 x 10(-6)).
|
18346983 |
2008 |