|
Pediatric Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study investigated whether the combined effects of FTO and MC4R increase the risk of obesity in children and adolescents living in Northwest China.
|
30896429 |
2019 |
|
Pediatric Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found no association of FTO rs9939609 with obesity in children and adolescents (p = 0.67).
|
29238857 |
2019 |
|
Pediatric Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis shows that the FTO rs9939609 polymorphism in the gene is a risk factor for obesity in children and adolescents with the presence of the A allele, both homozygous genotype AA situation, as heterozygous AT.
|
30104138 |
2019 |
|
Pediatric Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The combined presence of three or more high-risk alleles of both the FTO and MC4R genes confers a 4-fold higher risk for obesity in children and adolescents of Greek origin, although these risk alleles have no impact on the metabolic alterations observed in these obese children and adolescents.
|
25402378 |
2016 |
|
Pediatric Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The fat mass and obesity-associated gene (FTO) variant rs9939609 has been associated with increased risk of developing obesity in children and adults.
|
26222659 |
2015 |
|
Pediatric Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Three known adult BMI-associated loci (FTO, MC4R and ADCY3) and one childhood obesity locus (OLFM4) reached genome-wide significance (PWald < 1.13 × 10(-8)) with BMI at 8 years and/or change over time.
|
25953783 |
2015 |
|
Pediatric Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
According to the multiple group approach of SEM, we see an interaction between SES and FTO with respect to their effect on childhood obesity (Δχ(2) = 7.3, df = 2, P = 0.03).
|
25135377 |
2015 |
|
Pediatric Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the association analysis between the FTO gene variant and risk of childhood obesity, compared with the rs1421085TT wide-type genotype, rs1421085 CC and CT/CC genotypes were associated with 59% and 71% increased risks of childhood obesity (adjusted OR = 1.59, 95%CI = 1.00-2.53 for CC; adjusted OR = 1.71, 95%CI = 1.10-2.65 for CT/CC), while the rs17817449 T > G variant was not associated with the significantly increased risk of childhood obesity.
|
24331679 |
2014 |
|
Pediatric Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that variant in FTO gene was significantly associated with increased risk of overweight/obesity in children and adolescents (OR=1.35; 95%CI: 1.27-1.44; P<0.001).
|
24278475 |
2013 |
|
Pediatric Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Variants in the FTO gene have been associated with obesity in children, but this association has not been shown with other biomarkers.
|
24289790 |
2013 |
|
Pediatric Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Children from The Western Australian Pregnancy Cohort (Raine; n=1,506) Study were genotyped at 17 genetic loci shown to be associated with childhood obesity (FTO, MC4R, TMEM18, GNPDA2, KCTD15, NEGR1, BDNF, ETV5, SEC16B, LYPLAL1, TFAP2B, MTCH2, BCDIN3D, NRXN3, SH2B1, MRSA) and an obesity-risk-allele-score was calculated as the total number of 'risk alleles' possessed by each individual.
|
23349760 |
2013 |
|
Pediatric Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene has been widely associated with childhood obesity in several European cohorts.
|
21798115 |
2012 |
|
Pediatric Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children.
|
23091647 |
2012 |
|
Pediatric Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data confirm the association between FTO and adiposity suggesting that FTO is a childhood obesity susceptibility gene.
|
20379142 |
2010 |
|
Pediatric Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The effects of FTO on body weight, body composition, and the risk of developing overweight and obesity in children, adolescents, and adults are analyzed in this review.
|
20090391 |
2009 |
|
Pediatric Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.
|
18335027 |
2008 |
|
Pediatric Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Variation in FTO contributes to childhood obesity and severe adult obesity.
|
17496892 |
2007 |