|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
T2D was associated with TCF7L2 and FTO but not HLA, and the risk conferred by sweetened beverages appeared modified by FTO (OR 1.45, 95% CI 1.21-1.73 in non-carriers).
|
30656477 |
2020 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
FTO rs9939609 was associated with risk of obesity in additive model (p=0.031), recessive (p=0.033) and with altered WC in all models.
|
30713021 |
2020 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
The Role of FTO Genotype in the Association Between FTO Gene Expression and Anthropometric Measures in Obese and Overweight Adolescent Boys.
|
30373434 |
2020 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the interactions effects of FTO rs9939609 and lifestyle factors on obesity indices in early adolescence.
|
31402168 |
2020 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Previous studies could prove a fundamental role of the Fat mass and obesity associated gene (Fto) within obesity; however, its functional role within different cell types is less understood.
|
31801409 |
2020 |
|
Malignant neoplasm of breast
|
0.500 |
Biomarker
|
disease |
BEFREE |
The expression of m6A methylases (METTL3, METTL14 and WTAP) and demethylases (FTO and ALKBH5) were analyzed by using ONCOMINE and The Cancer Genome Atlas databases and in 36 pairs of BC and adjacent non-cancerous tissue.
|
30953473 |
2019 |
|
Malignant neoplasm of breast
|
0.500 |
Biomarker
|
disease |
BEFREE |
Considering FTO's critical role in many diseases, FTO may become a new promising target for the diagnosis and treatment of various diseases in the near future, especially for specific types of cancers, such as acute myeloid leukaemia, glioblastoma and breast cancer.
|
30465076 |
2019 |
|
Malignant neoplasm of breast
|
0.500 |
Biomarker
|
disease |
BEFREE |
FTO promoted breast cancer cell proliferation, colony formation and metastasis in vitro and in vivo.
|
30922314 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine the association between omentin Val109Asp and FTO rs9939609 polymorphisms and insulin resistance in newly-diagnosed T2D patients.
|
31200723 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
For the rs9939609 variant (FTO), the dominant model AA/(AT+TT) revealed significant association with T2D [odds ratio (OR)=2.03, P=0.021], but was non-significant post correction for multiple testing (P=0.002).
|
31823921 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These results demonstrated that miR-495 could promote the transformation of macrophages into M1-type pro-inflammatory macrophages by inhibiting the expression of its target gene FTO, and aggravate the insulin resistance and adipose tissue inflammation in T2D mice, which provided a certain theoretical basis for the targeted treatment of T2D.
|
31709454 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association of FTO Gene Variant (rs8050136) with Type 2 Diabetes and Markers of Obesity, Glycaemic Control and Inflammation.
|
30867643 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Overweight and TCF7L2 also significantly interacted in relation to type 2 diabetes (AP, 0.26; 95% CI, 0.19 to 0.33), but no interaction was observed with high-risk genotypes of HLA or FTO.
|
31125083 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Single SNP analysis showed that genetic variants in SLC30A10, TMEM18, GNPDA2, PRL, TFAP2B, BDNF, MTCH2, FTO, and MC4R were nominally associated with waist circumference (WC), BMI, and risk for abdominal or general obesity in the untreated patients with type 2 diabetes, as well as in the total group of patients with type 2 diabetes (untreated and treated) (p < 0.05).
|
31167208 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations of the FTO gene were associated with obesity and type 2 diabetes determinants in the European population, notably raised blood levels of insulin and glucose.
|
30621571 |
2019 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
FTO rs9939609 and rs9935401 and MC4R rs12970134 and rs17782313 interactions were analysed through generalized multifactor dimensionality reduction, and logistic regression models were used to calculate the risk of the relationship between genotypes and obesity.
|
30896429 |
2019 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The fat mass and obesity-associated gene (FTO) rs9939609 A-allele is associated with higher acyl-ghrelin (AG) concentrations, higher energy intake, and obesity, although exercise may mitigate rs9939609 A-allele-linked obesity risk.
|
31504106 |
2019 |
|
Obesity
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lifestyle modification may exert its effects on obesity through changes in the expression level of the FTO and IRX3 genes.
|
31126299 |
2019 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
More importantly, this study revealed that the association between having a risk allele of the FTO gene and BMI (and obesity status) is largely concentrated among individuals who were heavier at birth.
|
31702102 |
2019 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of the 47 subjects, 15 were of normal risk for obesity whereas 32 were carriers of the FTO gene risk alleles.
|
31477138 |
2019 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Influence of FTO Polymorphism rs9939609 on Obesity, Some Clinical Features, and Disturbance of Carbohydrate Metabolism in Patients with Psoriasis.
|
30733965 |
2019 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to investigate whether the genetic risk score (GRS) based on previously associated obesity polymorphisms (SNP) rs9939609 (fat mass and obesity-associated (FTO)), rs6548238 (transmembrane protein 18 (TMEM18)) and rs16835198 (fibronectin type III domain containing 5 (FNDC5)) could serve as a predictor for anthropometric characteristics in a sample of Brazilian children and adolescents.
|
30311592 |
2019 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
FTO genotypes associated with risk for obesity and loss of control of eating, specifically rs1421085, may interact with insecure attachment in a way that may exacerbate binge eating among women with BED.
|
30822753 |
2019 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Altered postprandial responses in hunger hormones and metabolic flexibility may not be a mechanism by which FTO is associated with higher BMI and obesity in healthy, normal-weighted individuals.
|
31635368 |
2019 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of interest, a markedly lower frequency of the FTO rs9939609 obesity risk A-allele was found in BED patients (0.290) in relation to the control group (0.402).
|
30677719 |
2019 |