WDR77, WD repeat domain 77, 79084

N. diseases: 31; N. variants: 0
Disease: Carcinogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.070 Biomarker phenotype BEFREE In this study, we used in vivo genetic studies to further investigate the role of Wdr77 in prostate tumorigenesis. 29706654 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.070 Biomarker phenotype BEFREE PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 symmetric dimethylation and coordinates with PRMT5-WDR77/CRL4B complex to promote tumorigenesis. 29846670 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.070 AlteredExpression phenotype BEFREE Altered expression of target genes is associated with re-activation of PRMT5 and p44 during lung tumorigenesis. 27480244 2016
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.070 AlteredExpression phenotype BEFREE In addition, newly accumulating evidence implicates PRMT5 and MEP50 expression levels and their methyltransferase activity in cancer tumorigenesis, and, significantly, as markers of poor clinical outcome, marking them as potential oncogenes. 25662273 2015
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.070 Biomarker phenotype BEFREE Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis. 25277535 2014
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.070 Biomarker phenotype BEFREE Our results suggest that p44/wdr77 controls cellular proliferation during lung development, and this growth process is reactivated during lung tumorigenesis. 22665061 2013
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.070 Biomarker phenotype BEFREE These findings strongly suggest that p44 plays a role in mediating the effects of hormones during tumorigenesis in breast. 19840198 2010