|
Sendai virus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
LGP2 mRNA is induced by interferon, dsRNA treatments, or Sendai virus infection and acts as a feedback inhibitor for antiviral signaling.
|
17020950 |
2006 |
|
Influenza
|
0.010 |
Biomarker
|
disease |
BEFREE |
LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3.
|
22837208 |
2012 |
|
Picornaviridae Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
LGP2 is known to work in synergy with melanoma differentiation-associated gene 5 (MDA5) to promote the antiviral response induced by picornavirus infection.
|
29958302 |
2018 |
|
Foot-and-Mouth Disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Evidence of LGP2 proteolysis was also detected during FMDV infection.
|
29958302 |
2018 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Exome-wide association study of plasma lipids in >300,000 individuals.
|
29083408 |
2017 |
|
Vancomycin intermediate staphylococcus aureus infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
FKBP8 inhibits virus-induced RLR-VISA signaling.
|
30267576 |
2019 |
|
Virus Diseases
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Foot-and-mouth disease virus infection inhibits LGP2 protein expression to exaggerate inflammatory response and promote viral replication.
|
28406479 |
2017 |
|
Multiple Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Further, we provide initial evidence for combinatorial effects of polymorphic variants in the RIG-I, LGP2 and IFIH1 genes on MS risk.
|
25288302 |
2014 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
Here, we show that LGP2 enhances apoptosis by upregulating apoptosis regulatory genes during viral infection.
|
31799626 |
2020 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
However, the role of another important innate immune cytosolic sensor, laboratory of genetics and physiology 2 (LGP2), in the cancer behavior of NB remains unclear.
|
30179292 |
2018 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
However, the role of another important innate immune cytosolic sensor, laboratory of genetics and physiology 2 (LGP2), in the cancer behavior of NB remains unclear.
|
30179292 |
2018 |
|
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In short, LGP2 was effective in promoting poly (I:C)-induced NB suppression and cytoplasmic LGP2 can serve as an independent favorable prognostic factor in NB patients.
|
30179292 |
2018 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In short, LGP2 was effective in promoting poly (I:C)-induced NB suppression and cytoplasmic LGP2 can serve as an independent favorable prognostic factor in NB patients.
|
30179292 |
2018 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In short, LGP2 was effective in promoting poly (I:C)-induced NB suppression and cytoplasmic LGP2 can serve as an independent favorable prognostic factor in NB patients.
|
30179292 |
2018 |
|
Encephalitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In vitro interaction analyses using purified recombinant proteins confirmed that the single-stranded Theiler's murine encephalitis virus genome enhanced the interaction between LGP2 and PACT.
|
29032202 |
2017 |
|
Influenza A virus infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
It is intriguing that LGP2, a host protein induced during influenza A virus infection, downregulates the host antiviral IFN response.
|
22837208 |
2012 |
|
Hepatitis C
|
0.020 |
Biomarker
|
disease |
BEFREE |
Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses.
|
28090671 |
2017 |
|
Aeromonas hydrophila infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Meanwhile, RLR family consist of three conserved members (RIG-I, MDA5 and LGP2) as well as two adaptors (IPS-1 and STING) in C. idella. mRNA expression analyses of TLRs, RLRs and their adaptors indicated that most members are sustainably expressed in multiple tissues before and after grass carp reovirus (GCRV) or Aeromonas hydrophila infection, while TLR9, TLR20a/b, TLR25, TIRAP, SARM1 and STING are transiently expressed in specific tissues.
|
28559111 |
2017 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
Our findings not only reveal a role of mitochondria in RLR mediated antiviral signaling but also suggest that mitochondria contribute to the regulation of persistent viral infection.
|
23830853 |
2013 |
|
Duck viral enteritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, these findings indicated that MDA5 restricted DEV replication and LGP2 plays a critical role in MDA5-mediated antiviral activity against DEV.
|
31675523 |
2019 |
|
Cardiovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
PACT is required for MDA5-mediated immunoresponses triggered by Cardiovirus infection via interaction with LGP2.
|
29032202 |
2017 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
PBRM1 was found to be downregulated in primary tissues from patients with CRC or IBD, and its expression correlated negatively with that of RLR genes and interferon-stimulated genes in CRC samples.
|
28940253 |
2018 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Polyinosine-polycytidylic acid [pIC] is a synthetic dsRNA that acts as an immune agonist of TLR3 and RLR to activate dendritic and natural killer cells that can kill tumor cells. pIC can also trigger apoptosis in pancreatic ductal adenocarcinoma cells (PDAC) but its mechanism of action is obscure.
|
25205107 |
2014 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Positive cytoplasmic LGP2 expression in tumor tissues could predict a favorable outcome in NB patients independent of other prognostic factors.
|
30179292 |
2018 |