|
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Exome-wide association study of plasma lipids in >300,000 individuals.
|
29083408 |
2017 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
Here, we show that LGP2 enhances apoptosis by upregulating apoptosis regulatory genes during viral infection.
|
31799626 |
2020 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I, melanoma-differentiation-associated gene 5 (MDA5), and LGP2, function as cytoplasmic virus sensor proteins during viral infection.
|
29939295 |
2018 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
TRIM31 was recruited to mitochondria after viral infection and specifically regulated antiviral signaling mediated by RLR pattern-recognition receptors.
|
27992402 |
2017 |
|
Virus Diseases
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Foot-and-mouth disease virus infection inhibits LGP2 protein expression to exaggerate inflammatory response and promote viral replication.
|
28406479 |
2017 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
RIG-I-like receptors (RLRs: RIG-I, MDA5 and LGP2) play a major role in the innate immune response against viral infections and detect patterns on viral RNA molecules that are typically absent from host RNA.
|
24743923 |
2014 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
Our findings not only reveal a role of mitochondria in RLR mediated antiviral signaling but also suggest that mitochondria contribute to the regulation of persistent viral infection.
|
23830853 |
2013 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
Using LGP2(+/+) and LGP2(-/-) mouse cells, we show that endogenous LGP2 decreased IFN production during H3N2 virus infection 3- to 4-fold.
|
22837208 |
2012 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
Results indicate that LGP2 can inhibit antiviral signaling independently of dsRNA or virus infection intermediates by engaging in a protein complex with IPS-1.
|
17020950 |
2006 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
However, the role of another important innate immune cytosolic sensor, laboratory of genetics and physiology 2 (LGP2), in the cancer behavior of NB remains unclear.
|
30179292 |
2018 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
However, the role of another important innate immune cytosolic sensor, laboratory of genetics and physiology 2 (LGP2), in the cancer behavior of NB remains unclear.
|
30179292 |
2018 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Together, our findings indicate a possible role of PACT in regulating the Cardiovirus-triggered immune responses mediated by MDA5 and LGP2, which opens the door to novel therapeutic strategies in interferon-related autoimmune diseases and cancer.
|
29032202 |
2017 |
|
Hepatitis C
|
0.020 |
Biomarker
|
disease |
BEFREE |
Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses.
|
28090671 |
2017 |
|
Hepatitis C
|
0.020 |
Biomarker
|
disease |
BEFREE |
Q-MSI confirmed previously reported RLR interactions and revealed an interaction between HCV helicase and LGP2.
|
28483922 |
2017 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Together, our findings indicate a possible role of PACT in regulating the Cardiovirus-triggered immune responses mediated by MDA5 and LGP2, which opens the door to novel therapeutic strategies in interferon-related autoimmune diseases and cancer.
|
29032202 |
2017 |
|
Hepatitis
|
0.010 |
Biomarker
|
group |
BEFREE |
Q-MSI revealed previously unknown RNA mitochondrial receptor orientations, and the interaction between the viral RNA receptor called LGP2 with the RNA helicase encoded by the hepatitis virus.
|
30471070 |
2019 |
|
Hepatitis A
|
0.010 |
Biomarker
|
disease |
BEFREE |
Q-MSI revealed previously unknown RNA mitochondrial receptor orientations, and the interaction between the viral RNA receptor called LGP2 with the RNA helicase encoded by the hepatitis virus.
|
30471070 |
2019 |
|
West Nile Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
While LGP2 functions to modulate inflammatory signaling, RIG-I and MDA5 together are essential for M1 macrophage polarization in vivo and the control of WNV infection through potential downstream control of ATF4 and SMAD4 to regulate target gene expression for cell polarization.
|
31409781 |
2019 |
|
Duck viral enteritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, these findings indicated that MDA5 restricted DEV replication and LGP2 plays a critical role in MDA5-mediated antiviral activity against DEV.
|
31675523 |
2019 |
|
Vancomycin intermediate staphylococcus aureus infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
FKBP8 inhibits virus-induced RLR-VISA signaling.
|
30267576 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
PBRM1 was found to be downregulated in primary tissues from patients with CRC or IBD, and its expression correlated negatively with that of RLR genes and interferon-stimulated genes in CRC samples.
|
28940253 |
2018 |
|
Foot-and-Mouth Disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Evidence of LGP2 proteolysis was also detected during FMDV infection.
|
29958302 |
2018 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Positive cytoplasmic LGP2 expression in tumor tissues could predict a favorable outcome in NB patients independent of other prognostic factors.
|
30179292 |
2018 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In short, LGP2 was effective in promoting poly (I:C)-induced NB suppression and cytoplasmic LGP2 can serve as an independent favorable prognostic factor in NB patients.
|
30179292 |
2018 |