Acute myocardial infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Selected microRNAs (miR-1, miR-133a, and miR-499) were measured in a cohort of 122 patients from the PRAGUE-18 study (ticagrelor vs. prasugrel in AMI treated with primary percutaneous coronary intervention (pPCI)).
|
31781298 |
2019 |
Acute myocardial infarction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Circulating miR-1 level was significantly higher in AMI group than in non-AMI group (P < 0.001).
|
31611081 |
2019 |
Acute myocardial infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-1, miR-499 and miR-208 are sensitive markers to diagnose sudden death due to early acute myocardial infarction.
|
31240830 |
2019 |
Acute myocardial infarction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In mice, we find that AMI is accompanied by an increase in circulating levels of myo-miRs, with miR-1, 208, and 499 predominantly in circulating exosomes and miR-133 in the non-exosomal component.
|
30814518 |
2019 |
Acute myocardial infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Following the identification of cardiac-specific microRNA miR-208a in circulation, more non-coding RNAs (miR-1, miR-499 and miR-133) have been identified as biomarkers not only for the diagnosis of AMI but also for prognosis post infarction.
|
29698386 |
2018 |
Acute myocardial infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
This may be that miR-1 is reported as a biomarker of acute myocardial infarction.
|
30319429 |
2018 |
Acute myocardial infarction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mir-1 and miR-29b plasma levels post-AMI correlate with IV changes.
|
28663047 |
2017 |
Acute myocardial infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular, miR-133a/b (5 studies), miR-208a/b (6 studies), and miR-499 (7 studies) were well studied and found to be significant diagnostic and/or prognostic markers across different cardiovascular disease progression stages. miR-1 and miR-145b are potential biomarkers of ACS; miR-1 with higher sensitivity for all acute myocardial infarction (AMI), and miR-145 for STEMI and worse outcome of AMI.
|
27357636 |
2016 |
Acute myocardial infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although miR-1 and miR-208b decreased (1.4-fold) and increased (1.2-fold), respectively, in the AMI samples compared to the controls, the significance of these changes was limited by our sample size.
|
26046358 |
2015 |
Acute myocardial infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
For biological validation, RNA from 12 representative probands, extracted with all 6 kits (n = 72), was reverse transcribed and mRNAs (matrix metalloproteinase 9, arginase 1) and miRNAs (miR133a, miR1), shown to be altered by AMI, were analyzed.
|
25469788 |
2014 |
Acute myocardial infarction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that circulating miR-1, -133a, -208b, and -499 may be useful biomarkers in acute myocardial infarction patients but that these miRNAs are not superior to cardiac troponin T for the diagnosis of acute myocardial infarction.
|
23420161 |
2013 |
Acute myocardial infarction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of miRNA (miR)-1 and miR-133a were increased significantly in patients not only with acute myocardial infarction but also with unstable angina pectoris and Takotsubo cardiomyopathy without elevation of serum creatine phosphokinase or cardiac troponin.
|
21642241 |
2011 |