|
Lung diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Expression of Iroquois genes is up-regulated during early lung development in the nitrofen-induced pulmonary hypoplasia.
|
21238641 |
2011 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The odds ratios (OR) showed that IRX3 rs3751723 was associated with risk of obesity in additive model (p=0.017), recessive model (p=0.016) and with high BF% in all models.
|
30713021 |
2020 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bioinformatics tools were used to evaluate the correlations between hypothalamic Irx3 and neurotransmitters, markers of thermogenesis and obesity related phenotypes.
|
30522931 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IRX3 expression has been functionally associated in obesity-associated long-distance susceptibility loci, but the effect of the IRX3 genetic variants on human obesity and obesity-related metabolism remains uncertain.
|
28316138 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The Iroquois homeodomain transcription factor gene IRX3 is expressed in the developing nervous system, limb buds, and heart, and transcript levels specify obesity risk in humans.
|
29346763 |
2018 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The analysis of the FTO-IRX3 locus revealed high LD and high order gene-gene interactions for BMI linked obesity.
|
27650258 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to test IRX3's roles in the browning program and to evaluate the association between the genetic variants in IRX3 and human obesity.
|
28988979 |
2017 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is the first study to reveal that genetic variants of both FTO and IRX3 genes are in high linkage disequilibrium (LD) and are associated with obesity risk in North Indians.
|
26440677 |
2016 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has been recently suggested that although the obesity related SNPs reside in the first intron of FTO, they may not only impact FTO but mediate their obesity effects via nearby genes (notably RPGRIP1L and IRX3).
|
26627093 |
2015 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Consistent with this, obesity-associated single nucleotide polymorphisms are associated with expression of IRX3, but not FTO, in human brains.
|
24646999 |
2014 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genomewide association studies (GWAS) have indicated that SNPs on a chromosome 16 locus encompassing FTO, as well as IRX3, 5, 6, FTM and FTL are robustly associated with human obesity.
|
25224490 |
2014 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockdown of its orthologue in zebrafish, irx3a, increased the number of pancreatic ghrelin-producing epsilon cells and decreased the number of insulin-producing beta-cells and glucagon-producing alpha-cells, thereby suggesting a direct link of pancreatic IRX3 function to both obesity and type 2 diabetes.
|
20080751 |
2010 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Moreover, miR-377 restoration significantly abrogated IRX3-induced proliferation, migration and invasion of SMMC7721 cells.
|
27222047 |
2016 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Genetic Irx3 gain and loss of function studies in human microvascular endothelial cells resulted in the modulation of EC migration during wound healing, chemotaxis and invasion, and tubulogenesis.
|
25512384 |
2015 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Consistent with a role for IRX3 in tubular differentiation, gene sets linked to Notch signaling, Rho signaling, and ion channel activity were enriched in tumors with high IRX3 expression, while WTs with low expression were enriched for gene sets linked to cell cycle progression.
|
20847289 |
2010 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Uniquely, hypermethylation of the CGI within an IRX3 exon was correlated with over-expression of IRX3 in tumor tissues and cell lines relative to normal brain samples.
|
16952911 |
2006 |
|
Nephroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In human foetal kidney and Wilms tumour, IRX5 expression was already activated in early proliferative blastema, whereas IRX3 protein levels peaked at tubular differentiation.
|
30246301 |
2019 |
|
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Moreover, some SNPs in intron locations of the FTO gene exert their effects on body mass index, body composition and breast cancer risk through change of the homeobox transcription factor iriquois 3 (IRX3) gene expression level.
|
29220587 |
2018 |
|
Lymphoid leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of IRX3 alone was sufficient to immortalize hematopoietic stem and progenitor cells (HSPCs) in myeloid culture and induce lymphoid leukemias in vivo.
|
29346763 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Combined IRX3 and Hoxa9 expression in murine HSPCs impeded normal T-progenitor differentiation in lymphoid culture and substantially enhanced the morphologic and phenotypic differentiation block of AML in myeloid leukemia transplantation experiments through suppression of a terminal myelomonocytic program.
|
29346763 |
2018 |
|
Acute leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We now report a functional role for IRX3 in human acute leukemia.
|
29346763 |
2018 |
|
Childhood T Acute Lymphoblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although transcript levels are very low in normal human bone marrow cells, high IRX3 expression is found in ∼30% of patients with acute myeloid leukemia (AML), ∼50% with T-acute lymphoblastic leukemia, and ∼20% with B-acute lymphoblastic leukemia, frequently in association with high-level HOXA gene expression.
|
29346763 |
2018 |
|
Childhood B Acute Lymphoblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although transcript levels are very low in normal human bone marrow cells, high IRX3 expression is found in ∼30% of patients with acute myeloid leukemia (AML), ∼50% with T-acute lymphoblastic leukemia, and ∼20% with B-acute lymphoblastic leukemia, frequently in association with high-level HOXA gene expression.
|
29346763 |
2018 |
|
Adult T Acute Lymphoblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although transcript levels are very low in normal human bone marrow cells, high IRX3 expression is found in ∼30% of patients with acute myeloid leukemia (AML), ∼50% with T-acute lymphoblastic leukemia, and ∼20% with B-acute lymphoblastic leukemia, frequently in association with high-level HOXA gene expression.
|
29346763 |
2018 |
|
Adult B Acute Lymphoblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although transcript levels are very low in normal human bone marrow cells, high IRX3 expression is found in ∼30% of patients with acute myeloid leukemia (AML), ∼50% with T-acute lymphoblastic leukemia, and ∼20% with B-acute lymphoblastic leukemia, frequently in association with high-level HOXA gene expression.
|
29346763 |
2018 |