|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
IRX1, SOX1 and MSX1 with risk associated SNP loci may serve as candidate biomarkers for diagnosis and prognosis of GC.
|
25982683 |
2015 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Here, we identified protein arginine methyltransferase 5 (PRMT5) as a major upstream regulator of IRX1 for determining GC progression.
|
29802960 |
2018 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer.
|
21602894 |
2011 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma.
|
20440264 |
2010 |
|
Stomach Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Over expression of miR-544 contributes to the inactivation and low-expression of IRX1 in gastric cancer.
|
22934698 |
2013 |
|
Malignant neoplasm of stomach
|
0.040 |
Biomarker
|
disease |
BEFREE |
Here, we identified protein arginine methyltransferase 5 (PRMT5) as a major upstream regulator of IRX1 for determining GC progression.
|
29802960 |
2018 |
|
Malignant neoplasm of stomach
|
0.040 |
Biomarker
|
disease |
BEFREE |
IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer.
|
21602894 |
2011 |
|
Malignant neoplasm of stomach
|
0.040 |
Biomarker
|
disease |
BEFREE |
IRX1, SOX1 and MSX1 with risk associated SNP loci may serve as candidate biomarkers for diagnosis and prognosis of GC.
|
25982683 |
2015 |
|
Malignant neoplasm of stomach
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Over expression of miR-544 contributes to the inactivation and low-expression of IRX1 in gastric cancer.
|
22934698 |
2013 |
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis.
|
23456299 |
2013 |
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that IRX1 and HLA-DRB1 are the strongest genetic factors for RF production in RA.
|
26815016 |
2016 |
|
Secondary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
As results, the remarkable suppression on peritoneal spreading and pulmonary metastasis of SGC-7901 cells by IRX1 transfectant correlates to reduced angiogenesis as well as VM formation.
|
21602894 |
2011 |
|
Secondary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together, these results identify IRX1 as a prometastatic gene, implicate IRX1 hypomethylation as a potential molecular marker for lung metastasis, and suggest that epigenetic reversion of IRX1 activation may be beneficial for controlling osteosarcoma metastasis.
|
25822025 |
2015 |
|
North Carolina macular dystrophy
|
0.020 |
Biomarker
|
disease |
BEFREE |
The 5 mutations V1 to V5 segregated perfectly in the 102 affected and 39 unaffected members of the 12 NCMD families.
|
26507665 |
2016 |
|
North Carolina macular dystrophy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Duplication events downstream of IRX1 cause North Carolina macular dystrophy at the MCDR3 locus.
|
28790370 |
2017 |
|
Squamous cell carcinoma of the head and neck
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Five candidate genes: septin 9 (SEPT9), sodium-coupled monocarboxylate transporter 1 (SLC5A8), functional smad-suppressing element on chromosome 18 (FUSSEL18), early B-cell factor 3 (EBF3), and iroquois homeobox 1 (IRX1) were methylated in 27% to 67% of the HNSCC patient samples tested.
|
18559491 |
2008 |
|
Squamous cell carcinoma of the head and neck
|
0.020 |
Biomarker
|
disease |
BEFREE |
IRX1 may have potential as a biomarker for HNSCC and should be assessed in a larger cohort.
|
24337411 |
2014 |
|
Squamous cell carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
LHGDN |
Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma.
|
18559491 |
2008 |
|
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, the results suggest that genetic variants of the IRX1 gene may contribute to the pathogenesis of CHD.
|
28358424 |
2017 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, IRX1 was identified to be localized to the cytoplasm in the adjacent normal brain and World Health Organization grade I glioma, whereas was identified to be present in the nucleus in higher grade glioma.
|
29328446 |
2018 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pyrosequencing assay was performed to validate the methylation status of TGF-β signaling components, EBF3 and IRX1 genes in RASFs and osteoarthritis (OA) SFs.
|
23456299 |
2013 |
|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, these results identify IRX1 as a prometastatic gene, implicate IRX1 hypomethylation as a potential molecular marker for lung metastasis, and suggest that epigenetic reversion of IRX1 activation may be beneficial for controlling osteosarcoma metastasis.
|
25822025 |
2015 |
|
Seminoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Several additional differentially expressed genes were identified in teratomas (EGR1 and MMP7), yolk sac tumors (PTPN13 and FN1), and seminomas (NR6A1, DPPA4, and IRX1).
|
16306258 |
2005 |
|
Androgen-Insensitivity Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Student's t-test was used to compare the IRX1 expression between AIS patients and controls.
|
30862593 |
2019 |
|
Chronic gastritis
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
IRX1 methylation was studied by methylation specific polymerase chain reaction (MSP) and bisulfate sequencing polymerase chain reaction (BSP) methods in gastric mucosa tissues from H. pylori-positive chronic gastritis patients or H. pylori-negative chronic gastritis patients.
|
21649733 |
2011 |