|
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.
|
31015462 |
2019 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
In a recent study, we identified five tumor suppressive genes (IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18) as frequently methylated in HNSCC biopsies using a global methylation analysis via restriction landmark genomic scanning.
|
20029986 |
2010 |
|
North Carolina macular dystrophy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Duplication events downstream of IRX1 cause North Carolina macular dystrophy at the MCDR3 locus.
|
28790370 |
2017 |
|
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, the results suggest that genetic variants of the IRX1 gene may contribute to the pathogenesis of CHD.
|
28358424 |
2017 |
|
Lung diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Expression of Iroquois genes is up-regulated during early lung development in the nitrofen-induced pulmonary hypoplasia.
|
21238641 |
2011 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma.
|
20440264 |
2010 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
IRX1 is a newly identified tumor suppressor gene and hypermethylation involves the decreased expression in gastric cancer.
|
22934698 |
2013 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Here, we use homozygous knockout mutants of zebrafish to demonstrate that the IRX1 gene is a true tumor suppressor gene and mechanism of the tumor suppression is mediated by repressing cell cycle progression.
|
31450023 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
In serum from osteosarcoma patients, the presence of IRX1 hypomethylation in circulating tumor DNA reduced lung metastasis-free survival.
|
25822025 |
2015 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
IRX1, SOX1 and MSX1 with risk associated SNP loci may serve as candidate biomarkers for diagnosis and prognosis of GC.
|
25982683 |
2015 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Here, we identified protein arginine methyltransferase 5 (PRMT5) as a major upstream regulator of IRX1 for determining GC progression.
|
29802960 |
2018 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer.
|
21602894 |
2011 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma.
|
20440264 |
2010 |
|
Malignant neoplasm of stomach
|
0.040 |
Biomarker
|
disease |
BEFREE |
Here, we identified protein arginine methyltransferase 5 (PRMT5) as a major upstream regulator of IRX1 for determining GC progression.
|
29802960 |
2018 |
|
Malignant neoplasm of stomach
|
0.040 |
Biomarker
|
disease |
BEFREE |
IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer.
|
21602894 |
2011 |
|
Malignant neoplasm of stomach
|
0.040 |
Biomarker
|
disease |
BEFREE |
IRX1, SOX1 and MSX1 with risk associated SNP loci may serve as candidate biomarkers for diagnosis and prognosis of GC.
|
25982683 |
2015 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Together, these results identify IRX1 as a prometastatic gene, implicate IRX1 hypomethylation as a potential molecular marker for lung metastasis, and suggest that epigenetic reversion of IRX1 activation may be beneficial for controlling osteosarcoma metastasis.
|
25822025 |
2015 |
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis.
|
23456299 |
2013 |
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that IRX1 and HLA-DRB1 are the strongest genetic factors for RF production in RA.
|
26815016 |
2016 |
|
Secondary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
As results, the remarkable suppression on peritoneal spreading and pulmonary metastasis of SGC-7901 cells by IRX1 transfectant correlates to reduced angiogenesis as well as VM formation.
|
21602894 |
2011 |
|
Secondary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together, these results identify IRX1 as a prometastatic gene, implicate IRX1 hypomethylation as a potential molecular marker for lung metastasis, and suggest that epigenetic reversion of IRX1 activation may be beneficial for controlling osteosarcoma metastasis.
|
25822025 |
2015 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In this study, we found that knockout of zebrafish Irx1 gene induced hyperplasia and tumorigenesis in the multiple organs where the gene was expressed.
|
31450023 |
2019 |
|
North Carolina macular dystrophy
|
0.020 |
Biomarker
|
disease |
BEFREE |
The 5 mutations V1 to V5 segregated perfectly in the 102 affected and 39 unaffected members of the 12 NCMD families.
|
26507665 |
2016 |