|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Comparison of diseased human brain tissue with age- and sex-matched controls yielded significant decreases (60-88%) in calbindin protein and mRNA in the substantia nigra (Parkinson disease), in the corpus striatum (Huntington disease), in the nucleus basalis (Alzheimer disease), and in the hippocampus and nucleus raphe dorsalis (Parkinson, Huntington, and Alzheimer diseases) but not in the cerebellum, neocortex, amygdala, or locus ceruleus.
|
2140897 |
1990 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have shown that most of the BFCN in the human brain contain the calcium-binding protein calbindin-D28K (CB), a large proportion lose their CB in the course of normal aging, and the BFCN which degenerate in AD lack CB.
|
26417681 |
2015 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Decreased expression of the calcium-binding protein calbindin-D<sub>28K</sub> (CB) might be a susceptibility factor for AD.
|
31668966 |
2020 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using basal forebrain cholinergic neurons (BFCNs) as a model and immunohistochemistry, we have demonstrated significant age-related loss of the calcium-binding protein calbindin-D(28K) (CB) from BFCN, which was associated with tangle formation and degeneration in AD.
|
24461366 |
2014 |
|
Parkinson Disease
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Comparison of diseased human brain tissue with age- and sex-matched controls yielded significant decreases (60-88%) in calbindin protein and mRNA in the substantia nigra (Parkinson disease), in the corpus striatum (Huntington disease), in the nucleus basalis (Alzheimer disease), and in the hippocampus and nucleus raphe dorsalis (Parkinson, Huntington, and Alzheimer diseases) but not in the cerebellum, neocortex, amygdala, or locus ceruleus.
|
2140897 |
1990 |
|
Huntington Disease
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Comparison of diseased human brain tissue with age- and sex-matched controls yielded significant decreases (60-88%) in calbindin protein and mRNA in the substantia nigra (Parkinson disease), in the corpus striatum (Huntington disease), in the nucleus basalis (Alzheimer disease), and in the hippocampus and nucleus raphe dorsalis (Parkinson, Huntington, and Alzheimer diseases) but not in the cerebellum, neocortex, amygdala, or locus ceruleus.
|
2140897 |
1990 |
|
Seizures
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
In a subset of APdE9 mice, seizure phenotype was associated with a loss of calbindin-D28k immunoreactivity in dentate granular cells and ectopic expression of neuropeptide Y in mossy fibers.
|
19295151 |
2009 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Treatment with calbindin-D28K antisense oligodeoxynucleotides, which significantly decreased calbindin-D28K expression, rendered these cells vulnerable again to ALS IgG toxicity.
|
8692898 |
1996 |
|
Renal Cell Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among 154 newly diagnosed cases and 308 matched controls, RCC was associated with higher whole blood lead [OR = 2.0; 95% confidence interval (CI), 1.0-3.9; quartile 4 (Q4) vs. Q1, P(trend) = 0.022] and CALB1 rs1800645 (P(trend) = 0.025, minor 'T' allele frequency = 0.34).
|
22086884 |
2012 |
|
Kidney Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Suppression of calbindin D28K in estrogen-induced hamster renal tumors.
|
15698544 |
2004 |
|
Multiple Endocrine Neoplasia Type 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We digested the DNA samples with various restriction endonucleases, conducted standard Southern blotting, and searched for restriction fragment length polymorphisms for the following candidate genes (probe names in parentheses): multiple endocrine neoplasia (MEN) type 1 (pMCMP.1, pHBI59, p3C7, and pTHH26), MEN 2a (MCK2 and cTB14.34), basic fibroblast growth factor (pHFL1-7), (Ca2+,Mg2+)ATPase isoform 4 (hPMCA4), membrane Na/Ca exchanger (cNC28 M-A), PTH (pPTH-LF), and calbindin-D28K (pSKCalb).
|
1517376 |
1992 |
|
Multiple Endocrine Neoplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We digested the DNA samples with various restriction endonucleases, conducted standard Southern blotting, and searched for restriction fragment length polymorphisms for the following candidate genes (probe names in parentheses): multiple endocrine neoplasia (MEN) type 1 (pMCMP.1, pHBI59, p3C7, and pTHH26), MEN 2a (MCK2 and cTB14.34), basic fibroblast growth factor (pHFL1-7), (Ca2+,Mg2+)ATPase isoform 4 (hPMCA4), membrane Na/Ca exchanger (cNC28 M-A), PTH (pPTH-LF), and calbindin-D28K (pSKCalb).
|
1517376 |
1992 |
|
Retroviridae Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Expression of calbindin-D28K in motoneuron hybrid cells after retroviral infection with calbindin-D28K cDNA prevents amyotrophic lateral sclerosis IgG-mediated cytotoxicity.
|
8692898 |
1996 |
|
Chronic myeloproliferative disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We further found that the number of c-Fos-immunopositive and calbindin-D28K-immunonegative cells in the MPNc, but not in the CALB-SDN, was significantly smaller in sexually experienced males than in sexually inexperienced males.
|
30170041 |
2018 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
N-methyl-D-aspartate receptor and calbindin-containing neurons in the anterior cingulate cortex in schizophrenia and bipolar disorder.
|
18585682 |
2008 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
Nevertheless, there are several replicated positive findings in BD, including decreased cortical thickness and glial density in subgenual anterior cingulate cortex, reduced neuronal density in some amygdalar nuclei, and decreased calbindin-positive neuron density in prefrontal cortex.
|
30127470 |
2018 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
BEFREE |
<b>Aim:</b> The authors aimed to study cognitive-enhancement- and neuroprotective-effects of Brahmi on novel object recognition memory and GABAergic neuronal density, defined by the presence of calcium binding proteins (CBPs; calbindin (CB), parvalbumin (PV), and calretinin (CR)) in a sub-chronic (2 mg/kg, Bid, ip) phencyclidine (PCP) rat model of schizophrenia.
|
31118643 |
2019 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
BEFREE |
N-methyl-D-aspartate receptor and calbindin-containing neurons in the anterior cingulate cortex in schizophrenia and bipolar disorder.
|
18585682 |
2008 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
PSYGENET |
We report reductions in somatostatin and vasoactive intestinal peptide mRNAs in prefrontal and orbitofrontal cortices in bipolar disorder (n=31) and schizophrenia (n=35) compared to controls (n=34) and increased calbindin mRNA in schizophrenia.
|
24674775 |
2014 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
PSYGENET |
These observations suggest that, in schizophrenia, a number of CB-containing cells that normally do not express NR2A might become NR2A-expressing or, perhaps not mutually exclusively, the number of CB-expressing cells might be increased and these cells express NR2A.
|
18585682 |
2008 |
|
Kidney Diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Assessment of biomarkers of drug-induced kidney injury in cynomolgus monkeys treated with a triple reuptake inhibitor.
|
21258088 |
2011 |
|
Kidney Diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Genomic-derived markers for early detection of calcineurin inhibitor immunosuppressant-mediated nephrotoxicity.
|
21865292 |
2011 |
|
Hyperbilirubinemia
|
0.210 |
Biomarker
|
disease |
BEFREE |
Immunoreactive staining for the calcium-binding proteins calbindin and parvalbumin in lower brainstem auditory nuclei shows abnormalities in areas susceptible to the effects of hyperbilirubinemia and provides a sensitive new way to assess bilirubin toxicity in the auditory system.
|
12204357 |
2002 |
|
Hyperbilirubinemia
|
0.210 |
Biomarker
|
disease |
RGD |
Immunoreactive staining for the calcium-binding proteins calbindin and parvalbumin in lower brainstem auditory nuclei shows abnormalities in areas susceptible to the effects of hyperbilirubinemia and provides a sensitive new way to assess bilirubin toxicity in the auditory system.
|
12204357 |
2002 |
|
Hyperbilirubinemia, Hereditary
|
0.200 |
Biomarker
|
disease |
RGD |
Changes in calcium-binding protein expression in the auditory brainstem nuclei of the jaundiced Gunn rat.
|
12204357 |
2002 |