|
spinal cord involvement
|
0.010 |
Biomarker
|
disease |
BEFREE |
Spinal cord involvement in MPTP-treated mice extends to Calbindin D28 KDa immune-reactive neurons other than motor neurons within lamina VII.
|
31721049 |
2020 |
|
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 5
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Abbreviations</b>: ACSF: artificial cerebrospinal fluid; AMC: aminomethylcoumarin; BPAN: beta-propeller protein-associated neurodegeneration; CALB1: calbindin 1; CNS: central nervous system; DCN: deep cerebellar nuclei; fEPSP: field excitatory postsynaptic potential; IC: internal capsule; ID: intellectual disability; ISH: <i>in situ</i> hybridization; KO: knockout; LTP: long-term potentiation; MBP: myelin basic protein; MGP: medial globus pallidus; PtdIns3P: phosphoinositide phosphatidylinositol-3-phosphate; WDR45B: WD repeat domain 45B; WIPI1: WD repeat domain, phosphoinositide interacting 1; WT: wild type.
|
31238825 |
2020 |
|
Sporadic Parkinson disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We demonstrate that depriving mDA neurons of NA input increases postnatal apoptosis and decreases cell survival in young adult rodents, with relative sparing of calbindin-positive subpopulations known to be resistant to degeneration in PD.
|
31734438 |
2020 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated the differential sensitivity of PCs in the valproate acid (VPA) mouse model of autism by estimating the linear density of PCs immununolabelled with calbindin in the cerebellum of males and females.
|
30461560 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that CALB1 is a direct target of miR-454-3p and downregulation of CALB1 by miR-454-3p suppressed NSCLC cell functions, which may shed light on its potential application in NSCLC therapy.
|
30638403 |
2019 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to determine the CB immunoreactivity in hippocampal dentate gyrus of patients who underwent epilepsy surgery for drug-resistant TLE with and without comorbid depression and/or memory deficits.
|
31191739 |
2019 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to determine the CB immunoreactivity in hippocampal dentate gyrus of patients who underwent epilepsy surgery for drug-resistant TLE with and without comorbid depression and/or memory deficits.
|
31191739 |
2019 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of Calbindin-D28k in Diabetes-Associated Advanced Glycation End-Products-Induced Renal Proximal Tubule Cell Injury.
|
31262060 |
2019 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Role of Calbindin-D28k in Diabetes-Associated Advanced Glycation End-Products-Induced Renal Proximal Tubule Cell Injury.
|
31262060 |
2019 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of calbindin-D28k in diabetic nephropathy still remains unclear.
|
31262060 |
2019 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Calbindin-D28k siRNA in vivo delivery could enhance renal fibrosis in <i>db</i>/<i>db</i> diabetic mice.
|
31262060 |
2019 |
|
Linear atrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We then studied sexually dimorphic features of several well-characterised sexual dimorphisms: calbindin-immunoreactive neurones in the medial preoptic area (CALB-SDN), tyrosine hydroxylase neurones in the anteroventral periventricular nucleus, and vasopressin-immunoreactive neurones originating in the bed nucleus of the stria terminalis and their projections in the lateral septum.
|
30920021 |
2019 |
|
Harlequin Fetus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thirty days after HI injury (at P40), GFAP scores in the hippocampus (p < 0.001, r = -0.47) and CA field (p < 0.001, r = -0.39) of posterior brain sections inversely correlated with their respective Calb1 expression.
|
30861522 |
2019 |
|
Parkinsonian Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Recruitment of calbindin into nigral dopamine neurons protects against MPTP-Induced parkinsonism.
|
30161282 |
2019 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The aim of this study was to determine the CB immunoreactivity in hippocampal dentate gyrus of patients who underwent epilepsy surgery for drug-resistant TLE with and without comorbid depression and/or memory deficits.
|
31191739 |
2019 |
|
Forgetful
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Late Calb1 deficit after HI may be the result of persistent astrogliosis and can lead to memory impairment, particularly in female mice.
|
30861522 |
2019 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, the present study suggested that CALB1 may act as an oncogene in ovarian cancer by inhibiting the p53 pathway.
|
31059057 |
2019 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, the present study suggested that CALB1 may act as an oncogene in ovarian cancer by inhibiting the p53 pathway.
|
31059057 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, the present study suggested that CALB1 may act as an oncogene in ovarian cancer by inhibiting the p53 pathway.
|
31059057 |
2019 |
|
Mental deterioration
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Heterochronic parabiosis (shared blood circulation) of AD transgenic mice with young healthy mice did not reduce amyloidosis and microglial activation in AD mice, but reversed the loss of synaptophysin and calbindin (critical synaptic proteins, indicators of cognitive decline in AD) in the dentate gyrus, and the abnormal expression, in the hippocampus, of many genes involved in key neuronal signaling pathways.
|
28384033 |
2018 |
|
Malignant mesothelioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Genetically modified MM cell lines with medium (MSTO-211H and ZL5) or low (SPC111) endogenous CR expression levels were generated that overexpress either CR's closest homologue calbindin-D28k (CB) or parvalbumin (PV), the latter considered as a "pure" Ca<sup>2+</sup> buffer protein.
|
30545133 |
2018 |
|
Chronic myeloproliferative disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We further found that the number of c-Fos-immunopositive and calbindin-D28K-immunonegative cells in the MPNc, but not in the CALB-SDN, was significantly smaller in sexually experienced males than in sexually inexperienced males.
|
30170041 |
2018 |
|
Amnesia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we report that early-life stress suppressed calbindin levels in CA1 and dentate gyrus (DG) neurons, and calbindin knockdown in adult CA1 or DG excitatory neurons mimicked early-life stress-induced memory loss.
|
29069596 |
2017 |
|
Cerebral Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Effect of hyperthermia on calbindin-D 28k immunoreactivity in the hippocampal formation following transient global cerebral ischemia in gerbils.
|
29089991 |
2017 |
|
Transient Ischemic Attack
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that ischemic preconditioning can attenuate transient cerebral ischemia-caused damage to the pyramidal neurons in the hippocampal CA1 area through maintaining calbindin D28k immunoreactivity.
|
28761424 |
2017 |