|
Mesothelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Modulation of Calretinin Expression in Human Mesothelioma Cells Reveals the Implication of the FAK and Wnt Signaling Pathways in Conferring Chemoresistance towards Cisplatin.
|
31671889 |
2019 |
|
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunocytochemical studies on PF cell blocks allow: (a) to distinguish mesothelioma from reactive mesothelial proliferations (e.g. loss of BAP1 nuclear expression, complemented by the demonstration of p16 deletion using fluorescence in situ hybridization, indicate mesothelioma); (b) to separate mesothelioma from adenocarcinoma (e.g. calretinin, CK 5/6, WT-1 and D2-40 are markers of mesothelioma, whereas CEA, EPCAM, TTF-1, napsin A, and claudin 4 are markers of carcinoma); and (c) to reveal tumor origin in pleural metastases of an unknown primary site (e.g.
|
30354850 |
2019 |
|
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Calretinin (CR) is used as a positive marker for human malignant mesothelioma (MM) and is essential for mesothelioma cell growth/survival.
|
30555628 |
2018 |
|
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As calretinin and D2-40, the recognized positive markers of mesothelioma, are expressed in lung adenocarcinoma to some extent, novel markers with high specificity are desirable.
|
29327712 |
2018 |
|
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical markers for mesothelioma were positive for calretinin, cytokeratin AE1/AE3, and cytokeratin CAM5.2.
|
28463437 |
2017 |
|
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Calretinin as a blood-based biomarker for mesothelioma.
|
28558669 |
2017 |
|
Mesothelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our aim was to elucidate mechanisms regulating calretinin expression in mesothelioma.
|
26848772 |
2016 |
|
Mesothelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The specificity of the effect was confirmed by stable enhanced green fluorescent protein-CR expression in mesothelioma cell lines and subsequent downregulation.
|
23595591 |
2013 |
|
Mesothelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
(CK7 is common to all epithelial tumours, CEA can be expressed in clear cell carcinoma, WT1 is normally expressed in serous carcinoma, calretinin is expressed in mesothelioma and CK20 in colon carcinoma).
|
23265355 |
2013 |
|
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
There was positivity for vimentin, EMA, and cytokeratin 5/6 while WT1, calretinin, and CEA were negative; however, D2-40 showed diffuse membranous positivity in the epithelial areas and cytoplasmic positivity in the spindle areas confirming a mesothelioma.
|
21574263 |
2012 |
|
Mesothelioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Calretinin (CALB2) is a member of the EF-hand family of Ca(2+)-binding proteins and is expressed in a majority of poorly differentiated colon carcinoma and additionally in mesothelioma of the epithelioid and mixed type.
|
19998412 |
2010 |
|
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To systematically investigate the sensitivity of calretinin and D2-40 antibodies in epithelioid and sarcomatoid areas of malignant mesotheliomas, a tissue microarray with 341 malignant mesotheliomas, including 112 epithelioid, 46 sarcomatoid and 183 biphasic tumors was constructed.
|
17361207 |
2007 |
|
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrate that the immunoreactivity observed in the mesotheliomas and their metastases investigated in this report is due to the concomitant presence of calretinin and the alternatively spliced form calretinin-22k.
|
15736446 |
2005 |
|
Mesothelioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is suggested that calretinin is active in the first steps of carcinogenesis in all human mesotheliomas and during several stages in the evolution towards malignancy.
|
11299732 |
2001 |