|
Adenocarcinoma Of Esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is possible that persistent acid reflux present in BE patients may increase the intracellular calcium, activate ROCK2 and thereby upregulate NOX5-S. High levels of reactive oxygen species derived from NOX5-S may cause DNA damage and thereby contribute to the progression from BE to EA.
|
26901778 |
2016 |
|
Adenocarcinoma Of Esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study we examined the role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in a Barrett's EA cell line FLO and a Barrett's cell line CP-A.
|
24699332 |
2014 |
|
Adenocarcinoma Of Esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The data suggest that NOX5-S may be important in the development of EA.
|
21525435 |
2011 |
|
Adenocarcinoma Of Esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
H(2)O(2)-induced increase in NOX5-S expression was significantly inhibited by knockdown of nuclear factor (NF)-κB1 p50 with p50 small interfering RNA (siRNA) in EA cell lines FLO and OE33.
|
21750116 |
2011 |
|
Adenocarcinoma Of Esophagus
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Therefore, we examined whether acid increases methylation of p16 gene promoter and whether NADPH oxidase NOX5-S mediates acid-induced p16 hypermethylation in a Barrett's cell line BAR-T and an EA cell line OE33.
|
20576920 |
2010 |
|
Adenocarcinoma Of Esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It is possible that bile acid reflux present in patients with BE may increase reactive oxygen species production and cell proliferation via activation of PI-PLCgamma2, ERK2 MAP kinase, and NADPH oxidase NOX5-S, thereby contributing to the development of EA.
|
20086178 |
2010 |
|
Adenocarcinoma Of Esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This increase in thymidine incorporation was significantly reduced by knockdown of NOX5-S. TGR5 mRNA and protein levels were significantly higher in OA tissues than in normal oesophageal mucosa or Barrett's mucosa.
|
19926617 |
2010 |
|
Adenocarcinoma Of Esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The mechanism(s) of NOX5-S overexpression in EA, however, is not fully understood.
|
17947454 |
2008 |
|
Adenocarcinoma Of Esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have shown that the NADPH oxidase NOX5-S may play an important role in the progression from Barrett's esophagus to esophageal adenocarcinoma (EA) by increasing cell proliferation and decreasing apoptosis.
|
17403674 |
2007 |
|
Adenocarcinoma Of Esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells.
|
16707484 |
2006 |
|
Barrett Esophagus
|
0.080 |
Biomarker
|
disease |
BEFREE |
We found that NADPH oxidase 5 (NOX5), mPGES-1 and iNOS were significantly increased in BE mucosa.
|
31700071 |
2019 |
|
Barrett Esophagus
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
We found that acid-induced increase in NOX5-S expression was significantly decreased by the Rho kinase (ROCK) inhibitor Y27632 in BE mucosal biopsies and FLO-1 EA cells.
|
26901778 |
2016 |
|
Barrett Esophagus
|
0.080 |
Biomarker
|
disease |
BEFREE |
In order to provide an unbiased extraction of the knowledge from the literature, a text-mining methodology was used to select genes that are involved in the BE progression, with the top candidate genes found to be TP53, CDKN2A, CTNNB1, CDH1, GPX3, and NOX5.
|
27415609 |
2016 |
|
Barrett Esophagus
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
NOX5 is highly expressed in malignant melanomas, prostate cancer and Barrett's oesophagus-associated adenocarcinomas, and in the last it is related to chronic gastro-oesophageal reflux and inflammation.
|
25818486 |
2015 |
|
Barrett Esophagus
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
It is possible that in BE acid reflux increases intracellular calcium, activates NOX5-S, and increases ROS production, which causes DNA damage, thereby contributing to the progression from BE to EA.
|
24699332 |
2014 |
|
Barrett Esophagus
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
It is possible that acid reflux present in BE patients may activate NOX5-S and increase production of reactive oxygen species, which in turn increase p16 promoter methylation, downregulate p16 expression, and increase cell proliferation, thereby contributing to the progression from BE to EA.
|
20576920 |
2010 |
|
Barrett Esophagus
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
We have shown that NADPH oxidase NOX5-S is overexpressed in Barrett's esophageal adenocarcinoma (EA) cells and may contribute to the progression from Barrett's esophagus (BE) to EA presumably by increasing cell proliferation and decreasing apoptosis (Fu X, Beer DG, Behar J, Wands J, Lambeth D, Cao W. J Biol Chem 281: 20368-20382, 2006).
|
17947454 |
2008 |
|
Barrett Esophagus
|
0.080 |
Biomarker
|
disease |
BEFREE |
We have shown that the NADPH oxidase NOX5-S may play an important role in the progression from Barrett's esophagus to esophageal adenocarcinoma (EA) by increasing cell proliferation and decreasing apoptosis.
|
17403674 |
2007 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Curcumin enhances cisplatin sensitivity by suppressing NADPH oxidase 5 expression in human epithelial cancer.
|
31423287 |
2019 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The exact pathophysiological significance of NOX5 remains unclear, but it seems to be important in the physiological regulation of sperm motility, vascular contraction and lymphocyte differentiation, and NOX5 hyperactivation has been implicated in cardiovascular disease, kidney injury and cancer.
|
30801870 |
2019 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Curcumin enhances cisplatin sensitivity by suppressing NADPH oxidase 5 expression in human epithelial cancer.
|
31423287 |
2019 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
The exact pathophysiological significance of NOX5 remains unclear, but it seems to be important in the physiological regulation of sperm motility, vascular contraction and lymphocyte differentiation, and NOX5 hyperactivation has been implicated in cardiovascular disease, kidney injury and cancer.
|
30801870 |
2019 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
NADPH oxidase 5 (NOX5) generated reactive oxygen species (ROS) have been implicated in signaling cascades that regulate cancer cell proliferation.
|
28762556 |
2017 |
|
Malignant neoplasm of prostate
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Similarly, increased normoxic HIF-1α expression and decreased p27<sup>Kip1</sup> expression were observed in stable NOX5-overexpressing clones of KARPAS 299 human lymphoma cells and in the human prostate cancer cell line, PC-3.
|
28762556 |
2017 |
|
Prostate carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Similarly, increased normoxic HIF-1α expression and decreased p27<sup>Kip1</sup> expression were observed in stable NOX5-overexpressing clones of KARPAS 299 human lymphoma cells and in the human prostate cancer cell line, PC-3.
|
28762556 |
2017 |