Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we found that a E3 ubiquitin ligase Peli1 is dramatically induced only in the substantia nigra (SN) of the human and mouse PD brains.
|
31142803 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutants which carry mutations in genes encoding mitochondrial ligases MUL1 and PARKIN are convenient Drosophila models of Parkinson's disease (PD).
|
31138137 |
2019 |
Parkinson Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ring finger protein 146 (RNF146) is an E3 ubiquitin ligase whose activity prevents poly (ADP-ribose) polymerase 1 (PARP1)-dependent neurodegeneration in Parkinson's disease (PD).
|
30974833 |
2019 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The allele T in the rs529974(+) MUL1 gene was susceptible to PD.
|
30793286 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dysregulation of mitophagy, whereby damaged mitochondria are labeled for degradation by the mitochondrial kinase PINK1 and E3 ubiquitin ligase Parkin with phosphorylated ubiquitin chains (p-S65 ubiquitin), may contribute to neurodegeneration in Parkinson's disease.
|
31801089 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
α-Synuclein (ASN) and parkin, a multifunctional E3 ubiquitin ligase, are two proteins that are associated with the pathophysiology of Parkinson's disease (PD).
|
29681024 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parkin is an E3 ubiquitin ligase involved in Parkinson's disease (PD).
|
30074231 |
2019 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the E3 ubiquitin ligase parkin are the most common known cause of autosomal recessive Parkinson's disease (PD), and parkin depletion may play a role in sporadic PD.
|
31406131 |
2019 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parkinson's disease (PD)-associated E3 ubiquitin ligase Parkin is enriched at glutamatergic synapses, where it ubiquitinates multiple substrates, suggesting that its mutation/loss-of-function could contribute to the etiology of PD by disrupting excitatory neurotransmission.
|
30200940 |
2018 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parkin encodes an E3 ubiquitin ligase, and mutations affecting its catalytic potential are implicated in autosomal recessive Parkinson's disease (PD).
|
29223129 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parkin, an E3 ubiquitin ligase and a Parkinson's disease (PD) related gene, translocates to impaired mitochondria and drives their elimination via autophagy, a process known as mitophagy.
|
30219582 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parkin functions as a multipurpose E3 ubiquitin ligase, and Parkin loss of function is associated with both sporadic and familial Parkinson's disease (PD).
|
29987020 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parkin, an E3 ubiquitin ligase, has been studied extensively in all major protein misfolding aggregating diseases, especially Parkinson's disease and Alzheimer's disease, but the role of parkin in TSEs remains unknown.
|
27430567 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mitochondrial kinase PTEN-induced putative kinase 1 (PINK1) and E3 ubiquitin ligase Parkin function in a common pathway to regulate mitochondrial homeostasis contributing to the pathogenesis of Parkinson disease.
|
28778978 |
2017 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parkin, an E3 ubiquitin ligase, is the most frequently mutated gene in hereditary Parkinson's disease.
|
28169962 |
2017 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease.
|
29180628 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
PARK2 encodes for the E3 ubiquitin ligase parkin and is implicated in the development of Parkinson's disease (PD).
|
28656059 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parkin is an E3 ubiquitin ligase originally characterized in the pathogenesis of Parkinson disease; however, its potential role in acute inflammatory processes and lung EC function remains largely unknown.
|
27693468 |
2017 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parkin (which encoded by Park2), an E3 ubiquitin ligase, is the most frequently mutated gene that has casually been linked to autosomal recessive early onset familial PD.
|
28086194 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parkin, a tumor suppressor and Parkinson's disease (PD) associated gene, is an E3 ubiquitin ligase crucial for mitophagy.
|
27148961 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Parkinson's disease (PD)-related protein F-box only protein 7 (Fbxo7) is the substrate-recognition component of the Skp1-Cullin-F-box protein E3 ubiquitin ligase complex.
|
27689878 |
2017 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson's Disease (PD).
|
28399880 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identifications of mutations in genes encoding PINK1 (PTEN-induced kinase 1) and Parkin (E3 ubiquitin ligase) in familial PD and their functional association with mitochondrial quality control provided further support to this hypothesis.
|
27911343 |
2017 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parkin, an E3 ubiquitin ligase, is the most frequently mutated gene in hereditary Parkinson's disease.
|
29138676 |
2017 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the genes encoding the mitochondrial kinase PINK1 and the E3 ubiquitin ligase Parkin cause autosomal recessive Parkinson's disease (PD).
|
27251035 |
2016 |