|
Hypercalcemia
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Vitamin D intoxication in an anephric child.
|
1115441 |
1975 |
|
Milk-Alkali Syndrome
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Vitamin D intoxication in an anephric child.
|
1115441 |
1975 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The best chance of cure lies in early diagnosis through the use of immunoreactive calcitonin measurement in family members at risk, and an aggressive surgical attack on the primary tumor and any cervical metastases.
|
1111937 |
1975 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The best chance of cure lies in early diagnosis through the use of immunoreactive calcitonin measurement in family members at risk, and an aggressive surgical attack on the primary tumor and any cervical metastases.
|
1111937 |
1975 |
|
Medullary carcinoma of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasma calcitonin measurement following calcium infusion is extremely useful as a screening procedure for the diagnosis of medullary thyroid carcinoma, when the patients are completely asymptomatic and routine thyroid function tests are normal.
|
1117836 |
1975 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The best chance of cure lies in early diagnosis through the use of immunoreactive calcitonin measurement in family members at risk, and an aggressive surgical attack on the primary tumor and any cervical metastases.
|
1111937 |
1975 |
|
Multiple Endocrine Neoplasia Type 2a
|
0.100 |
Biomarker
|
disease |
BEFREE |
The normal iPTH suppressibility in MEN 2b is consistent with the concept that the parathyroid disease in MEN 2a is genetically determined, and not secondary to MTC and high plasma calcitonin concentration.
|
950371 |
1976 |
|
Medullary carcinoma of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The normal iPTH suppressibility in MEN 2b is consistent with the concept that the parathyroid disease in MEN 2a is genetically determined, and not secondary to MTC and high plasma calcitonin concentration.
|
950371 |
1976 |
|
Familial (FPAH)
|
0.040 |
Biomarker
|
disease |
BEFREE |
Four cases of familial bone dysplasia with hyperphosphatasaemia were treated with synthetic human calcitonin.
|
1052783 |
1976 |
|
Bone Diseases, Developmental
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Hereditary bone dysplasia with hyperphosphatasaemia: response to synthetic human calcitonin.
|
1052783 |
1976 |
|
Hyperparathyroidism
|
0.020 |
Biomarker
|
disease |
BEFREE |
What role this apparent lack of calcitonin played in the development of hyperparathyroidism (or vis versa) needs clarification.
|
1244790 |
1976 |
|
Parathyroid Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
The normal iPTH suppressibility in MEN 2b is consistent with the concept that the parathyroid disease in MEN 2a is genetically determined, and not secondary to MTC and high plasma calcitonin concentration.
|
950371 |
1976 |
|
Hyperphosphatasemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hereditary bone dysplasia with hyperphosphatasaemia: response to synthetic human calcitonin.
|
1052783 |
1976 |
|
Medullary carcinoma of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The main characteristics of medullary carcinoma of the thyroid are its non-follicular histological appearance, resulting from its origin from the parafollicular C cells, its secretion of calcitonin, providing a relatively simple diagnostic test, and its equal sex incidence, in contrast to all other diseases of the thyroid.
|
20027 |
1977 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Patients with MTC have high basal or stimulated calcitonin values long before the tumor is detectable by scan or even later by palpation.
|
657681 |
1978 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Medullary thyroid carcinoma (M.C.T.) is a tumour of the calcitonin-secreting cells of the thyroid gland; it affects both lobes, has a variable malignant potential, and is often familial.
|
76933 |
1978 |
|
Medullary carcinoma of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The two persons with initially elevated values and three of the seven with increased values after pentagastrin injection were found at subsequent operation to have focal medullary carcinoma and parafollicular cell hyperplasia; after the operation immunoreactive calcitonin was undetectable in the plasma, even after stimulation.
|
679097 |
1978 |
|
Medullary carcinoma of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Medullary thyroid carcinoma (M.C.T.) is a tumour of the calcitonin-secreting cells of the thyroid gland; it affects both lobes, has a variable malignant potential, and is often familial.
|
76933 |
1978 |
|
Familial medullary thyroid carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with MTC have high basal or stimulated calcitonin values long before the tumor is detectable by scan or even later by palpation.
|
657681 |
1978 |
|
Medullary carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
The two persons with initially elevated values and three of the seven with increased values after pentagastrin injection were found at subsequent operation to have focal medullary carcinoma and parafollicular cell hyperplasia; after the operation immunoreactive calcitonin was undetectable in the plasma, even after stimulation.
|
679097 |
1978 |
|
Mass of thyroid gland
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Despite the availability of diagnostic plasma-calcitonin immunoassays, the condition is rarely considered in the initial assessment of a patient with a thyroid mass so that the is often disseminated by the time it is diagnosed, inadequate surgery is performed, and family members are not investigated.
|
76933 |
1978 |
|
Multiple Endocrine Neoplasia Type 2a
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum carcinoembryonic antigen (CEA) and calcitonin were assayed in 8 patients with medullary carcinoma of the thyroid (MCT) and 14 unaffected family members, from 4 pedigrees of Sipple's syndrome and one pedigree with inherited MCT.
|
476574 |
1979 |
|
Medullary carcinoma of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum carcinoembryonic antigen (CEA) and calcitonin were assayed in 8 patients with medullary carcinoma of the thyroid (MCT) and 14 unaffected family members, from 4 pedigrees of Sipple's syndrome and one pedigree with inherited MCT.
|
476574 |
1979 |
|
C-cell hyperplasia of thyroid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the glands with microscopic carcinoma the peak levels of histaminase occur in the areas of disease as defined by immunohistochemical staining of calcitonin; mean histaminase activity is the only one of the three parameters measured that distinguishes between C-cell hyperplasia and microscopic carcinoma (p less than .005).
|
115572 |
1979 |
|
Multiple endocrine neoplasia Type 2
|
0.080 |
Biomarker
|
disease |
BEFREE |
Serum carcinoembryonic antigen (CEA) and calcitonin were assayed in 8 patients with medullary carcinoma of the thyroid (MCT) and 14 unaffected family members, from 4 pedigrees of Sipple's syndrome and one pedigree with inherited MCT.
|
476574 |
1979 |