CALCA, calcitonin related polypeptide alpha, 796

N. diseases: 467; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Biomarker disease BEFREE Calcitonin (elcatonin [eCT]) has been used mainly for hypercalcemia and pain associated with osteoporosis. 30655691 2019
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Biomarker disease BEFREE The patient had longstanding hypercalcaemia and hyperparathyrodism refractory to calcimimetics, calcitonin, hormone and haemodialysis. 31088386 2019
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 GeneticVariation disease BEFREE Twenty-one patients with EPNS were detected: 16 with ectopic Cushing's syndrome (ECS), one with hypercalcaemia due to parathyroid hormone-related protein (PTHrP) secretion, three with hypercalcitonaemia and one patient with dual secretion of calcitonin and beta-human chorionic gonadotropin (β-HCG). 30280284 2019
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Biomarker disease BEFREE The patient was started on aggressive intravenous fluid hydration and intravenous calcitonin, after which her altered mental status resolved and both kidney function and hypercalcemia improved. 29480854 2018
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Biomarker disease BEFREE Her condition was complicated by hypercalcemia resistant to prolonged medical treatment with hyperhydration, diuretic and steroid but eventually the infant responded to high doses of calcitonin. 29915859 2018
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Biomarker disease BEFREE Rebound hypercalcemia (serum calcium, 3.1 to 4.3 mmol/L) was unresponsive to hyperhydration alone, requiring repeated doses of calcitonin or intravenous bisphosphonate treatment. 29211870 2018
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Biomarker disease BEFREE Treatment with calcitonin and cinacalcet could not control hypercalcemia. 29658374 2018
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Biomarker disease BEFREE The baby was managed symptomatically and specific treatment like pamidronate, calcitonin and steroid therapy were also administered to reduce hypercalcaemia. 30262523 2018
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Biomarker disease BEFREE His hypercalcemia continued to worsen with the initiation of MAI therapy but we were able to treat it successfully with pamidronate and calcitonin. 27620657 2017
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Biomarker disease BEFREE Our findings furthermore suggest that the tumoral production of calcitonin and PTHrP might have contributed to the increased bone mineral storage of calcium and thus probably attenuated the development of frank hypercalcemia. 17188588 2007
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Therapeutic disease CTD_human Pamidronate-induced tubulointerstitial nephritis with Fanconi syndrome in a patient with primary hyperparathyroidism. 12637657 2003
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Biomarker disease BEFREE In the patient with JD, the hypercalcemia was of early onset; chronic and nonprogressive; refractory to the administration of phosphate, glucocorticoid, and calcitonin; and accompanied by suppressed PTH levels as determined by two different immunoassays, an undetectable PTHrP level, increased excretion of nephrogenous cAMP (an in vivo bioassay of endogenous PTH production), decreased tubular reabsorption of phosphate, increased tubular reabsorption of calcium, increased biochemical indexes of bone turnover, and increased histological indexes of bone turnover on iliac bone histomorphometry after double tetracycline labeling. 8855805 1996
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 AlteredExpression disease BEFREE Involvement of the calcitonin/CGRP gene in Williams syndrome is postulated on the basis that Williams syndrome children often have infantile hypercalcemia and deficient expression of calcitonin, a hormone that lowers serum calcium levels. 1867260 1991
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Biomarker disease BEFREE Effects of glucocorticoids and calcitonin on parathyroid hormone-related protein (PTHrP) gene expression and PTHrP release in human cancer cells causing humoral hypercalcemia. 1938595 1991
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Biomarker disease BEFREE The calcitonin-CGRP gene in the infantile hypercalcaemia/Williams-Beuren syndrome. 2486208 1989
CUI: C0020437
Disease: Hypercalcemia
Hypercalcemia
0.400 Therapeutic disease CTD_human Vitamin D intoxication in an anephric child. 1115441 1975