|
C-cell hyperplasia of thyroid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thyroidectomy is recommended within the first year of life, preferably as soon as possible, due to the very early transformation of C cell hyperplasia to more aggressive tumours.Calcitonin levels may be less helpful.
|
24297502 |
2014 |
|
C-cell hyperplasia of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since calcitonin stimulation test indicated positive result, total thyroidectomy was performed 1 year after the bilateral adrenalectomy, and C-cell hyperplasia was diagnosed by histopathological examination.
|
24449023 |
2014 |
|
C-cell hyperplasia of thyroid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
GLP-1 receptor agonists stimulated calcitonin release, up-regulation of calcitonin gene expression, and subsequently C-cell hyperplasia in rats and, to a lesser extent, in mice.
|
20203154 |
2010 |
|
C-cell hyperplasia of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Following total thyroidectomy, one gene carrier had a histologically normal thyroid at age 46, following a mildly elevated calcitonin, one had C-cell hyperplasia at the age of 39, and one had a frank focus of carcinoma in the left thyroid lobe at the age of 45.
|
16736292 |
2006 |
|
C-cell hyperplasia of thyroid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although one child had a high stimulated calcitonin level, the histopathologic findings were normal; another child with high stimulated calcitonin levels showed C-cell hyperplasia on histopathologic examination.
|
11250764 |
2003 |
|
C-cell hyperplasia of thyroid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We report a 48-year-old woman suffering from primary hyperparathyroidism (parathormone 121-166 pg/ml, normal <72), bilateral diffuse and nodular C-cell hyperplasia (calcitonin after pentagastrin administration 156 pg/ml, normal <4.6), and papillary thyroid carcinoma.
|
12410354 |
2002 |
|
C-cell hyperplasia of thyroid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated prevalence and interrelationship of C-cell hyperplasia (CCH) and medullary thyroid carcinoma (MTC) in patients with thyroid and parathyroid disorders that showed increased calcitonin serum levels detected by routine screening.
|
9630179 |
1998 |
|
C-cell hyperplasia of thyroid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum calcitonin levels were normal, indicating no C-cell hyperplasia or medullary thyroid carcinoma.
|
7573303 |
1995 |
|
C-cell hyperplasia of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Screening of 11 family members spanning 4 generations revealed 7 subjects with corneal nerve thickening; of these subjects, 3 had abnormal pentagastrin-stimulated calcitonin studies, and these 3 subjects were each found to have C-cell hyperplasia or medullary thyroid carcinoma at surgery.
|
7829628 |
1995 |
|
C-cell hyperplasia of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a 5-year-old gene carrier with normal calcitonin values C-cell hyperplasia was evident.
|
7491529 |
1995 |
|
C-cell hyperplasia of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
None of these 68 subjects had medullary thyroid carcinoma or pheochromocytoma; 6 had elevated plasma calcitonin concentrations and underwent thyroidectomy but had only C-cell hyperplasia.
|
7915822 |
1994 |
|
C-cell hyperplasia of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The clinical implications of a positive calcitonin test for C-cell hyperplasia in genetically unaffected members of an MEN2A kindred.
|
8094268 |
1993 |
|
C-cell hyperplasia of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the authors' Medullary Screening Clinic, medullary thyroid cancer (MTC) or C-cell hyperplasia (CCH) has been identified in 26 relatives of 12 apparently "sporadic" patients from 56 families in which calcitonin (CT) testing has been performed.
|
2311068 |
1990 |
|
C-cell hyperplasia of thyroid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Basal immunoreactive calcitonin level was increased in 3 of 7 patients with C-cell hyperplasia alone, in 10 of 18 patients with nonmetastatic MCT, and in all 5 patients with metastatic MCT.
|
2742487 |
1989 |
|
C-cell hyperplasia of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Laboratory markers can also identify a precursor state for cancer, eg, elevated calcitonin levels in patients with familial medullary thyroid carcinoma and premalignant thyroid C-cell hyperplasia.
|
3731193 |
1986 |
|
C-cell hyperplasia of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
In 5 siblings of medullary thyroid carcinoma patients, PDN-21 and calcitonin were increased in response to iv pentagastrin, and we suspect C-cell hyperplasia or medullary thyroid carcinoma.
|
3902867 |
1985 |
|
C-cell hyperplasia of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Abnormal calcitonin secretion provides a reliable marker for the presence of medullary carcinoma of the thyroid (MCT) and its precursor form, C-cell hyperplasia (CCH).
|
6472115 |
1984 |
|
C-cell hyperplasia of thyroid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Electron microscopy was used to confirm the presence of C cell hyperplasia afte demonstration of elevated serum calcitonin values in three asymptomatic young women from two affected kindreds.
|
7275099 |
1981 |
|
C-cell hyperplasia of thyroid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the glands with microscopic carcinoma the peak levels of histaminase occur in the areas of disease as defined by immunohistochemical staining of calcitonin; mean histaminase activity is the only one of the three parameters measured that distinguishes between C-cell hyperplasia and microscopic carcinoma (p less than .005).
|
115572 |
1979 |