|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor suppressor MCPH1 regulates gene expression profiles related to malignant conversion and chromosomal assembly.
|
30809794 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MCPH1 (also known as BRIT1, BRCT-repeat inhibitor of hTERT expression) and BRCA1 are tumor suppressor genes that have been linked to telomerase expression.
|
29860064 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results indicate that downregulation of MCPH1 correlates with tumor progression in lung cancer, and hence MCPH1 may be an important tumor suppressor gene and a novel candidate therapeutic target in lung cancer.
|
29872322 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Phosphaturic mesenchymal tumour, mixed connective tissue variant (PMT-MCT), is a tumour of uncertain differentiation, characterised by 'smudgy/grungy' calcification and vitamin D-resistant phosphaturic osteomalacia.
|
28858396 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
BRCT-repeat inhibitor of hTERT expression (BRIT1) is involved in the invasion of tumors.
|
30337515 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The authors describe the case of an 8-year-old girl who was found to have PMT-MCT with involvement of the cerebellar hemisphere and a small tumor pedicle breaching the dura mater and involving the skull.
|
26722864 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MCPH1 also functions as a tumor suppressor in several human cancers as well as in mouse models.
|
27197793 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The microcephalin gene (MCPH1) [also known as inhibitor of human telomerase reverse transcriptase (hTERT) expression] is a tumor suppressor gene that is functionally involved in the DNA damage response.
|
25703238 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, in the past few years, many research studies have explored the role of MCPH1, a neurodevelopmental gene in several cancers and its tumor suppressor functions have been elucidated.
|
24560403 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study indicates for the first time that, in addition to its role in brain development, MCPH1 also functions as a tumor suppressor gene and is directly regulated by miR-27a.
|
25197360 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the cancer tissues, we identified low nuclear Microcephalin expression in high grade and advanced stage tumours (p<0.0001 and p = 0.0438 respectively).
|
24830737 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Monocarboxylate transporter isoform 1 (MCT1) is an important member of the proton-linked MCT family and has been reported in an array of human cancer cell lines and primary human tumors.
|
24012639 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, ectopic expression of BRIT1 effectively suppressed breast cancer cell proliferation and colony formation in vitro and tumor growth in vivo.
|
23729656 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We further observed that overexpression of MCPH1 decreased cellular proliferation, anchorage-independent growth in soft agar, cell invasion and tumor size in nude mice, indicating its tumor suppressive function.
|
23472065 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MCPH1 containing BRCT domain has been suggested as a tumor suppressor in breast and ovarian cancers.
|
23296058 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survival.
|
21505456 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Multivariate analysis of ductal carcinomas showed that microcephalin, together with lymph node involvement and tumour size were independent predictors of BCSS (P = 0.037).
|
20632086 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Among these genes, the microcephalin 1 (MCPH1/BRIT1) has never been tested as target of MSI in tumour series.
|
20638839 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Microcephalin expression is reduced in breast cancer cell lines and human tumors of the ovary and prostate.
|
18636190 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, the findings identify BRIT1 as a potential tumor suppressor.
|
17172830 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results identify BRIT1 as a crucial DNA damage regulator in the ATM/ATR pathways and suggest that it functions as a tumor suppressor gene.
|
16872911 |
2006 |