NEIL1, nei like DNA glycosylase 1, 79661

N. diseases: 15; N. variants: 0
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.500 Biomarker disease CTD_human In the current study, we report that exposure to a chronic oxidative stress in the form of a high-fat diet greatly accelerates the development of obesity in neil1(-/-) mice. 21285402 2011
CUI: C0028754
Disease: Obesity
Obesity 		0.500 Biomarker disease CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.310 Biomarker disease CTD_human Extrapolation of these data suggests that individuals who are heterozygous for these inactive variant neil1 alleles may be at increased risk for metabolic syndrome. 17389588 2007
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.310 Biomarker disease CTD_human These data suggest an important role for NEIL1 in the prevention of the diseases associated with the metabolic syndrome. 16446448 2006
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.300 Biomarker disease CTD_human Following a 5-wk high-fat diet challenge, neil1(-/-) mice gained significantly more body weight than neil1(+/+) littermates and had increased body fat accumulation and moderate to severe hepatic steatosis. 21285402 2011
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia 		0.300 Biomarker disease CTD_human Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. 21285402 2011
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.300 Biomarker phenotype CTD_human Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. 21285402 2011
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.300 Biomarker phenotype CTD_human A long-term high-fat diet also induced glucose intolerance as well as a significant reduction in mitochondrial DNA and protein content in neil1(-/-) mice. 21285402 2011
CUI: C0920563
Disease: Insulin Sensitivity
Insulin Sensitivity 		0.300 Biomarker phenotype CTD_human Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. 21285402 2011
CUI: C1706412
Disease: Lipidemias
Lipidemias 		0.300 Biomarker phenotype CTD_human Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. 21285402 2011
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.300 Biomarker disease CTD_human Following a 5-wk high-fat diet challenge, neil1(-/-) mice gained significantly more body weight than neil1(+/+) littermates and had increased body fat accumulation and moderate to severe hepatic steatosis. 21285402 2011
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.300 Biomarker disease CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.300 Biomarker disease CTD_human In the absence of exogenous oxidative stress, neil1 knockout (neil1-/-) and heterozygotic (neil1+/-) mice develop severe obesity, dyslipidemia, and fatty liver disease and also have a tendency to develop hyperinsulinemia. 16446448 2006
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias 		0.300 Biomarker group CTD_human In the absence of exogenous oxidative stress, neil1 knockout (neil1-/-) and heterozygotic (neil1+/-) mice develop severe obesity, dyslipidemia, and fatty liver disease and also have a tendency to develop hyperinsulinemia. 16446448 2006
CUI: C0598784
Disease: Dyslipoproteinemias
Dyslipoproteinemias 		0.300 Biomarker phenotype CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C1257963
Disease: Endogenous Hyperinsulinism
Endogenous Hyperinsulinism 		0.300 Biomarker disease CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C1257964
Disease: Exogenous Hyperinsulinism
Exogenous Hyperinsulinism 		0.300 Biomarker disease CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C1257965
Disease: Compensatory Hyperinsulinemia
Compensatory Hyperinsulinemia 		0.300 Biomarker disease CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.300 Biomarker disease CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006