NLRX1, NLR family member X1, 79671

N. diseases: 51; N. variants: 1
Disease: Colitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009319
Disease: Colitis
Colitis 		0.040 Biomarker disease BEFREE Cell-specificity studies using cre-lox mice demonstrate that the loss of NLRX1 in intestinal epithelial cells (IEC) recapitulate the increased sensitivity to DSS colitis observed in whole body <i>Nlrx1</i><sup>-/-</sup> mice. 29535731 2018
CUI: C0009319
Disease: Colitis
Colitis 		0.040 Biomarker disease BEFREE Metabolic effects of NLRX1 deficiency are observed in a CD4-specific knockout of NLRX1 within a <i>Citrobacter rodentium</i> model of colitis. 28159898 2017
CUI: C0009319
Disease: Colitis
Colitis 		0.040 Biomarker disease BEFREE This work shows that NLRX1 serves as a tumor suppressor in colitis-associated cancer (CAC) and sporadic colon cancer by keeping key tumor promoting pathways in check. 26971998 2016
CUI: C0009319
Disease: Colitis
Colitis 		0.040 Biomarker disease BEFREE Our findings showed that the regulatory function of PUA on colitis is NLRX1 dependent. 26714018 2015