LIN28A, lin-28 homolog A, 79727

N. diseases: 5; N. variants: 2
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.400 Biomarker group CTD_human Our work provides a mechanism for the coordinate repression of let-7 miRNAs observed in a subset of human cancers, and associates activation of LIN28 and LIN28B with poor clinical prognosis. 19483683 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.400 Biomarker group CTD_human LIN28 and LIN28b facilitate cellular transformation in vitro, and overexpression is associated with advanced disease across multiple tumor types. 19483683 2009
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness 		0.300 Biomarker phenotype CTD_human MeCP2 suppresses LIN28A expression via binding to its methylated-CpG islands in pancreatic cancer cells. 26910839 2016
CUI: C0007621
Disease: Neoplastic Cell Transformation
Neoplastic Cell Transformation 		0.300 Biomarker phenotype CTD_human Lin28 promotes transformation and is associated with advanced human malignancies. 19483683 2009
CUI: C0086692
Disease: Benign Neoplasm
Benign Neoplasm 		0.300 Biomarker group CTD_human Lin28 promotes transformation and is associated with advanced human malignancies. 19483683 2009