PALB2, partner and localizer of BRCA2, 79728

N. diseases: 260; N. variants: 410
Disease: Familial (FPAH) ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.070 GeneticVariation disease BEFREE Association of PALB2 sequence variants with the risk of familial and early-onset breast cancer in a South-American population. 25636233 2015
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.070 GeneticVariation disease BEFREE Mutations in the PALB2 gene are responsible for a small but significant percentage of cancer risks in familial breast and pancreatic cancer families. 25542327 2015
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.070 GeneticVariation disease BEFREE These data indicate that the PALB2*c.509_510delGA mutation is prevalent in about 1 in 400 breast cancer patients from Central and Eastern Europe, and the low occurrence of familial clustering is consistent with a moderate penetrance of this mutation. 24061862 2014
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.070 Biomarker disease BEFREE Therefore, PALB2 does not have a major causal role in familial clustering of PC and BC in non-BRCA1/2 families in the Dutch population. 22166947 2012
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.070 GeneticVariation disease BEFREE PALB2 mutations in familial breast and pancreatic cancer. 21365267 2011
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.070 GeneticVariation disease BEFREE Here we present data of a comprehensive mutation screening of the PALB2 gene in 818 familial cases of breast cancer from Germany. 21618343 2011
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH) 		0.070 GeneticVariation disease BEFREE In this study, we evaluated the frequency of PALB2 1592delT and 229delT mutations in 300 Korean breast cancer patients diagnosed with either familial or early-onset breast cancer. 20213081 2010