FZD3, frizzled class receptor 3, 7976

N. diseases: 39; N. variants: 4
Disease: Neural Tube Defects ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.030 PosttranslationalModification group BEFREE We explored the effects of variants spanning the FZD3 gene in NTDs and examined the role of aberrant methylation of the FZD3 promoter on gene expression in brain tissue in spina bifida. 25131656 2015
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.030 Biomarker group BEFREE The allele, genotype and haplotype frequencies were calculated and analyzed to examine the relationship between FZD3/FZD6 SNPs and NTDs. 24816679 2014
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.030 GeneticVariation group BEFREE Based on the highly penetrant occurrence of NTDs in double Fzd3/Fzd6(-/-) mutant mice, we investigated the role of the human orthologues, FZD3 and FZD6, by resequencing a cohort of 473 NTDs patients and 639 ethnically matched controls. 22045688 2012