RENAL DYSPLASIA, CYSTIC, SUSCEPTIBILITY TO
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia.
|
21922595 |
2012 |
RENAL DYSPLASIA, CYSTIC, SUSCEPTIBILITY TO
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia.
|
21922595 |
2012 |
RENAL DYSPLASIA, CYSTIC, SUSCEPTIBILITY TO
|
0.600 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
Mental Depression
|
0.370 |
Biomarker
|
disease |
BEFREE |
Bicaudal C homolog 1 gene (BICC1) in the medial prefrontal cortex (mPFC) has been implicated in major depressive disorder (MDD); however, less is known about the mechanisms of BICC1-induced depression.
|
31102751 |
2019 |
Depressive disorder
|
0.370 |
Biomarker
|
disease |
BEFREE |
Bicaudal C homolog 1 gene (BICC1) in the medial prefrontal cortex (mPFC) has been implicated in major depressive disorder (MDD); however, less is known about the mechanisms of BICC1-induced depression.
|
31102751 |
2019 |
Mental Depression
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the role of BDNF/TrkB signaling in the regulation of BICC1 expression in the chronic unpredictable stress (CUS) mouse model of depression.
|
28216067 |
2017 |
Depressive disorder
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the role of BDNF/TrkB signaling in the regulation of BICC1 expression in the chronic unpredictable stress (CUS) mouse model of depression.
|
28216067 |
2017 |
Mental Depression
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the effects of depression associated polymorphisms on the activity of the BICC1 promoter in amygdala neurones.
|
26440730 |
2016 |
Mental Depression
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Common SNPs in BICC1 and PCLO were associated with a 50% and 30% decreased risk of depression, respectively.
|
26391493 |
2016 |
Depressive disorder
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the effects of depression associated polymorphisms on the activity of the BICC1 promoter in amygdala neurones.
|
26440730 |
2016 |
Depressive disorder
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Common SNPs in BICC1 and PCLO were associated with a 50% and 30% decreased risk of depression, respectively.
|
26391493 |
2016 |
Mental Depression
|
0.370 |
Biomarker
|
disease |
BEFREE |
We also show that BICC1 is increased in the prefrontal cortex and hippocampus in the rat chronic unpredictable stress (CUS) model of depression.
|
25178406 |
2015 |
Depressive disorder
|
0.370 |
Biomarker
|
disease |
BEFREE |
We also show that BICC1 is increased in the prefrontal cortex and hippocampus in the rat chronic unpredictable stress (CUS) model of depression.
|
25178406 |
2015 |
Mental Depression
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Effect of genetic variant in BICC1 on functional and structural brain changes in depression.
|
22910460 |
2012 |
Mental Depression
|
0.370 |
Biomarker
|
disease |
PSYGENET |
Effect of genetic variant in BICC1 on functional and structural brain changes in depression.
|
22910460 |
2012 |
Depressive disorder
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Effect of genetic variant in BICC1 on functional and structural brain changes in depression.
|
22910460 |
2012 |
Depressive disorder
|
0.370 |
Biomarker
|
disease |
PSYGENET |
Effect of genetic variant in BICC1 on functional and structural brain changes in depression.
|
22910460 |
2012 |
Mental Depression
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) in BICC1 achieved suggestive evidence for association, which strengthened after imputation of ungenotyped markers, and in analysis of female depression cases.
|
20516156 |
2010 |
Mental Depression
|
0.370 |
Biomarker
|
disease |
PSYGENET |
Single nucleotide polymorphisms (SNPs) in BICC1 achieved suggestive evidence for association, which strengthened after imputation of ungenotyped markers, and in analysis of female depression cases.
|
20516156 |
2010 |
Depressive disorder
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) in BICC1 achieved suggestive evidence for association, which strengthened after imputation of ungenotyped markers, and in analysis of female depression cases.
|
20516156 |
2010 |
Depressive disorder
|
0.370 |
Biomarker
|
disease |
PSYGENET |
Single nucleotide polymorphisms (SNPs) in BICC1 achieved suggestive evidence for association, which strengthened after imputation of ungenotyped markers, and in analysis of female depression cases.
|
20516156 |
2010 |
Polycystic Kidney, Autosomal Dominant
|
0.310 |
Biomarker
|
disease |
BEFREE |
The repression of AC6 by Bicc1 might explain why cysts in ADPKD patients preferentially arise from distal tubules.
|
22641646 |
2012 |
Polycystic Kidney, Autosomal Dominant
|
0.310 |
GeneticVariation
|
disease |
ORPHANET |
Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia.
|
21922595 |
2012 |
Cystic kidney
|
0.230 |
GeneticVariation
|
disease |
BEFREE |
Several SAM-domain proteins that bind each other are mutated in patients with cystic kidneys or laterality defects, including the Ankyrin (ANK) and SAM domain-containing proteins ANKS6 and ANKS3, and the RNA-binding protein Bicc1.
|
29290488 |
2018 |
Cystic kidney
|
0.230 |
Biomarker
|
disease |
BEFREE |
Interestingly, Ofd1 and Bicc1 are both involved in renal cystogenesis and selected targets were shown to accumulate in two models of inherited renal cystic disease.
|
28450740 |
2017 |