BICC1, BicC family RNA binding protein 1, 80114

N. diseases: 52; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3275898
Disease: RENAL DYSPLASIA, CYSTIC, SUSCEPTIBILITY TO
RENAL DYSPLASIA, CYSTIC, SUSCEPTIBILITY TO 		0.600 Biomarker disease GENOMICS_ENGLAND Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia. 21922595 2012
CUI: C3275898
Disease: RENAL DYSPLASIA, CYSTIC, SUSCEPTIBILITY TO
RENAL DYSPLASIA, CYSTIC, SUSCEPTIBILITY TO 		0.600 GeneticVariation disease UNIPROT Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia. 21922595 2012
CUI: C3275898
Disease: RENAL DYSPLASIA, CYSTIC, SUSCEPTIBILITY TO
RENAL DYSPLASIA, CYSTIC, SUSCEPTIBILITY TO 		0.600 SusceptibilityMutation disease CLINVAR
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.370 Biomarker disease BEFREE Bicaudal C homolog 1 gene (BICC1) in the medial prefrontal cortex (mPFC) has been implicated in major depressive disorder (MDD); however, less is known about the mechanisms of BICC1-induced depression. 31102751 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.370 Biomarker disease BEFREE Bicaudal C homolog 1 gene (BICC1) in the medial prefrontal cortex (mPFC) has been implicated in major depressive disorder (MDD); however, less is known about the mechanisms of BICC1-induced depression. 31102751 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.370 AlteredExpression disease BEFREE In this study, we investigated the role of BDNF/TrkB signaling in the regulation of BICC1 expression in the chronic unpredictable stress (CUS) mouse model of depression. 28216067 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.370 AlteredExpression disease BEFREE In this study, we investigated the role of BDNF/TrkB signaling in the regulation of BICC1 expression in the chronic unpredictable stress (CUS) mouse model of depression. 28216067 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.370 GeneticVariation disease BEFREE Analysis of the effects of depression associated polymorphisms on the activity of the BICC1 promoter in amygdala neurones. 26440730 2016
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.370 GeneticVariation disease BEFREE Common SNPs in BICC1 and PCLO were associated with a 50% and 30% decreased risk of depression, respectively. 26391493 2016
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.370 GeneticVariation disease BEFREE Analysis of the effects of depression associated polymorphisms on the activity of the BICC1 promoter in amygdala neurones. 26440730 2016
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.370 GeneticVariation disease BEFREE Common SNPs in BICC1 and PCLO were associated with a 50% and 30% decreased risk of depression, respectively. 26391493 2016
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.370 Biomarker disease BEFREE We also show that BICC1 is increased in the prefrontal cortex and hippocampus in the rat chronic unpredictable stress (CUS) model of depression. 25178406 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.370 Biomarker disease BEFREE We also show that BICC1 is increased in the prefrontal cortex and hippocampus in the rat chronic unpredictable stress (CUS) model of depression. 25178406 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.370 GeneticVariation disease BEFREE Effect of genetic variant in BICC1 on functional and structural brain changes in depression. 22910460 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.370 Biomarker disease PSYGENET Effect of genetic variant in BICC1 on functional and structural brain changes in depression. 22910460 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.370 GeneticVariation disease BEFREE Effect of genetic variant in BICC1 on functional and structural brain changes in depression. 22910460 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.370 Biomarker disease PSYGENET Effect of genetic variant in BICC1 on functional and structural brain changes in depression. 22910460 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.370 GeneticVariation disease BEFREE Single nucleotide polymorphisms (SNPs) in BICC1 achieved suggestive evidence for association, which strengthened after imputation of ungenotyped markers, and in analysis of female depression cases. 20516156 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.370 Biomarker disease PSYGENET Single nucleotide polymorphisms (SNPs) in BICC1 achieved suggestive evidence for association, which strengthened after imputation of ungenotyped markers, and in analysis of female depression cases. 20516156 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.370 GeneticVariation disease BEFREE Single nucleotide polymorphisms (SNPs) in BICC1 achieved suggestive evidence for association, which strengthened after imputation of ungenotyped markers, and in analysis of female depression cases. 20516156 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.370 Biomarker disease PSYGENET Single nucleotide polymorphisms (SNPs) in BICC1 achieved suggestive evidence for association, which strengthened after imputation of ungenotyped markers, and in analysis of female depression cases. 20516156 2010
CUI: C0085413
Disease: Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Autosomal Dominant 		0.310 Biomarker disease BEFREE The repression of AC6 by Bicc1 might explain why cysts in ADPKD patients preferentially arise from distal tubules. 22641646 2012
CUI: C0085413
Disease: Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Autosomal Dominant 		0.310 GeneticVariation disease ORPHANET Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia. 21922595 2012
CUI: C0022679
Disease: Cystic kidney
Cystic kidney 		0.230 GeneticVariation disease BEFREE Several SAM-domain proteins that bind each other are mutated in patients with cystic kidneys or laterality defects, including the Ankyrin (ANK) and SAM domain-containing proteins ANKS6 and ANKS3, and the RNA-binding protein Bicc1. 29290488 2018
CUI: C0022679
Disease: Cystic kidney
Cystic kidney 		0.230 Biomarker disease BEFREE Interestingly, Ofd1 and Bicc1 are both involved in renal cystogenesis and selected targets were shown to accumulate in two models of inherited renal cystic disease. 28450740 2017