Thymic Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using tissue microarrays, the expression of COX-2, microsomal-PGES-1 and -PGES-2 (mPGES-1 and mPGES-2), as well as EGFR was evaluated in different subtypes of thymoma and thymic carcinomas.
|
16823844 |
2006 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We obtained evidence from two Caucasian study populations that the His298-allele of PTGES2 Arg298His confers to reduced risk of type 2 diabetes.
|
17566096 |
2007 |
Impaired glucose tolerance
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The PTGES2 Arg298His polymorphism was reinvestigated in a population-based cross-sectional study (Cooperative Health Research in the Augsburg Region) consisting of 239 individuals with impaired glucose tolerance, 226 with type 2 diabetes, and 863 normoglycemic controls.
|
17566096 |
2007 |
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Our study investigated the cellular localization and distribution of COX-1, COX-2, mPGES-1, and mPGES-2 in organ tissues from a mouse model of human hypertension.
|
17641732 |
2007 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In a recent study, we found an association of the minor PTGES2 Arg298His allele and lower risk of type 2 diabetes mellitus in the European Investigation into Cancer and Nutrition (EPIC) and Cooperative Health Research in the Augsburg Region (KORA) cohorts.
|
17979097 |
2007 |
Obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The prostaglandin E synthase 2 (PTGES2) gene maps to a locus linked to obesity and is involved in the synthesis of the antilipolytic compound prostaglandin E(2).
|
17979097 |
2007 |
Metabolic Syndrome X
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we employed our Metabolic Intervention Cohort Kiel (MICK) to assess the influence of the PTGES2 Arg298His polymorphism on a wider scale of parameters of the metabolic syndrome and postprandial metabolism.
|
17979097 |
2007 |
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease.
|
18631945 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Influence of a type 2 diabetes associated prostaglandin E synthase 2 polymorphism on blood prostaglandin E2 levels.
|
19268562 |
2009 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The H-allele of the R298H polymorphism in the prostaglandin E synthase 2 (PTGES2) gene was associated with lower risk of diabetes type 2.
|
19371221 |
2009 |
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicate that mPGES-1 and mPGES-2 may each play a role in CRC progression.
|
19412621 |
2009 |
Malignant neoplasm of prostate
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among non-obese individuals, the GG genotype of PTGES2 rs10987883 was associated with an increased risk for prostate cancer (unadjusted, recessive model OR = 3.23, 95% CI: 1.27-8.23).
|
21308720 |
2011 |
Prostate carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among non-obese individuals, the GG genotype of PTGES2 rs10987883 was associated with an increased risk for prostate cancer (unadjusted, recessive model OR = 3.23, 95% CI: 1.27-8.23).
|
21308720 |
2011 |
Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The inflammatory mediator prostaglandin E(2) (PGE(2)) is implicated in the pathogenesis of chronic inflammatory diseases including periodontitis; it is synthesized by cyclooxygenases (COX) and the prostaglandin E synthases mPGES-1, mPGES-2, and cPGES.
|
21435451 |
2011 |
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We found elevated expression of PTGES2 and PTGER4 and suppression of PTGER1 and PTGER3 in endometrial adenocarcinomas compared with normal endometrium.
|
21589857 |
2011 |
Carcinogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Here we investigated (a) the expression profile of the PGE synthase enzymes (PTGES, PTGES-2, PTGES-3) and PGE receptors (PTGER1-4) in endometrial adenocarcinomas compared with normal endometrium and (b) the role of PTGER4 in endometrial tumorigenesis in vivo.
|
21589857 |
2011 |
Thyroid Neoplasm
|
0.300 |
Biomarker
|
disease |
CTD_human |
Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
|
22387750 |
2012 |
Thyroid Gland Follicular Adenoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
|
22387750 |
2012 |
Thyroid carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
|
22387750 |
2012 |
Malignant neoplasm of endometrium
|
0.020 |
Biomarker
|
disease |
BEFREE |
Stable PTGES2-shRNA transfectants were generated in Ishikawa and Hec-1B endometrial cancer cell lines, and transfection efficiencies were confirmed by RT-PCR and Western blot analyses.
|
27230680 |
2016 |
Endometrial Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Stable PTGES2-shRNA transfectants were generated in Ishikawa and Hec-1B endometrial cancer cell lines, and transfection efficiencies were confirmed by RT-PCR and Western blot analyses.
|
27230680 |
2016 |
Kidney Failure, Acute
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overall, our study shows that mPGES-2 can protect renal tubular epithelial cells by regulating autophagy levels and aggravation of acute kidney injury by mPGES-2 down regulation is associated with autophagy inhibition and enhanced apoptosis.
|
28860615 |
2017 |
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression levels of eight enzymes (ALOX5, ALOX5AP, CYP2C8, CYP4F11, LTA4H, PLA2G4A, CYP2D6, PTGES2) correlated with the survival time of ESCC patients.
|
29636881 |
2018 |
Extrapulmonary Small Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression levels of eight enzymes (ALOX5, ALOX5AP, CYP2C8, CYP4F11, LTA4H, PLA2G4A, CYP2D6, PTGES2) correlated with the survival time of ESCC patients.
|
29636881 |
2018 |
Malignant neoplasm of endometrium
|
0.020 |
Biomarker
|
disease |
BEFREE |
In the present study, immunohistochemistry of PTGES2 was performed in 152 patients with endometrial cancer and in 66 patients with normal endometria.
|
30214592 |
2018 |