|
Arterial Occlusive Diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Participation of MCP-induced protein 1 in lipopolysaccharide preconditioning-induced ischemic stroke tolerance by regulating the expression of proinflammatory cytokines.
|
22196138 |
2011 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy.
|
31827283 |
2019 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy.
|
31827283 |
2019 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Our findings warrant future investigation of the roles of negative regulation of DR5 by MCPIP1 in cancer and in T-cell immunity.
|
29551769 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Our findings warrant future investigation of the roles of negative regulation of DR5 by MCPIP1 in cancer and in T-cell immunity.
|
29551769 |
2018 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Moreover, roles of regnase-1 in apoptosis and differentiation have also been described, but its involvement in cancer is yet to be fully recognized.
|
27935099 |
2017 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Moreover, roles of regnase-1 in apoptosis and differentiation have also been described, but its involvement in cancer is yet to be fully recognized.
|
27935099 |
2017 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Furthermore, we found that MCPIP1 expression was repressed in breast tumor cells, and overexpression of MCPIP1 induced apoptosis, whereas its depletion enhanced cancer cell proliferation.
|
26833120 |
2016 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Furthermore, we found that MCPIP1 expression was repressed in breast tumor cells, and overexpression of MCPIP1 induced apoptosis, whereas its depletion enhanced cancer cell proliferation.
|
26833120 |
2016 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Furthermore, we observed potential antagonism between MCPIP1 and Dicer function in human cancer and found a regulatory role of MCPIP1 in the signaling axis comprising miR-155 and its target c-Maf.
|
22055188 |
2011 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Furthermore, we observed potential antagonism between MCPIP1 and Dicer function in human cancer and found a regulatory role of MCPIP1 in the signaling axis comprising miR-155 and its target c-Maf.
|
22055188 |
2011 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to determine whether REG I affects cytokine production in cancer cells.
|
20056108 |
2010 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to determine whether REG I affects cytokine production in cancer cells.
|
20056108 |
2010 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Activity of MCPIP1 RNase in tumor associated processes.
|
31639017 |
2019 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Earlier, we showed a lack of expression of MCPIP1 in both primary tumors and several neuroblastoma cell lines.
|
27935099 |
2017 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
In patient-derived tumors and xenografts established in NOD-SCID or nude mice, low MCPIP1 levels correlated strongly with increased proliferation, tumor outgrowth, and vascularity.
|
28716897 |
2017 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Collectively, our results highlight that MCPIP1 is a new tumor suppressor in breast cancer that induces cell death by tipping the balance in favor of proapoptotic gene expression.
|
26833120 |
2016 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Our results showed a lack of MCPIP1 expression in primary neuroblastoma tumors.
|
24626857 |
2014 |
|
Autoimmune Diseases
|
0.040 |
PosttranslationalModification
|
group |
BEFREE |
Intriguingly, this TBK1-mediated phosphorylation of Regnase-1 was suppressed by the addition of dimethyl fumarate (DMF), an electrophilic small molecule that has been used to treat IL-17-related autoimmune diseases.
|
31718798 |
2020 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
MCP-1/MCPIP-1 Signaling Modulates the Effects of IL-1β in Renal Cell Carcinoma through ER Stress-Mediated Apoptosis.
|
31816951 |
2019 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
Regnase-1 is not only a key component in maintaining intracellular homeostasis but also a critical negative regulator in preventing autoimmune diseases and cancer development.
|
29777912 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We used RNA sequencing (RNA-Seq) technology to investigate changes in the transcriptome profile in the Caki-1 clear cell renal cell carcinoma (ccRCC) cells, which overexpress monocyte chemoattractant protein-induced protein 1 (MCPIP1).
|
29492220 |
2018 |
|
Autoimmune Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
Dysregulation of Regnase-1 has been described in a multitude of pathological states including autoimmune diseases, cancer and cardiovascular diseases.
|
28194024 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Overall, our results illuminate how MCPIP1 serves as a key nodal point in coordinating tumor growth, angiogenesis, and metastatic spread in ccRCC.<i></i>.
|
28716897 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Taken together, MCPIP1 contributes to the ccRCC development.
|
28197812 |
2017 |