|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cyclin‑dependent kinase 5 regulatory subunit‑associated protein 3 (CDK5RAP3 or C53) is involved in the development of various types of tumor, and alternative splicing of C53 results in numerous transcription variants that encode different isoforms.
|
30864700 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, low expression of CDK5RAP3 was correlated with more advanced TNM stage, increased tumor microvessel density, and poor prognosis.
|
31728130 |
2019 |
|
Vital capacity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Epilepsy, Generalized
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies.
|
30531953 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of CDK5RAP3 was closely related to the age of the patients (<i>P</i> = 0.035) and the T stage of the tumor (<i>P</i> = 0.017).
|
30228783 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CDK5RAP3 acts as a tumor suppressor in gastric cancer through inhibition of β-catenin signaling.
|
27793695 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Notably, LZAP, a putative tumor suppressor, has been linked to dephosphorylation of several of these substrates, including RelA, p38, Chk1, and Chk2.
|
28027003 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we showed that in CDK5RAP3 stable knockdown SMMC-7721 HCC cells, p14(ARF) tumor suppressor was upregulated at protein and mRNA levels, and ectopic expression of CDK5RAP3 was found to repress the transcription of p14(ARF).
|
22860085 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A yeast two-hybrid screening identified that TIP-1, through its single PDZ domain, binds to the carboxyl terminus of LZAP that has been studied as one tumor suppressor functioning through ARF binding and p53 activation.
|
23028987 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LZAP has been highly conserved during evolution and has been shown to function as a tumor suppressor in various cancers.
|
22028922 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Injection of IC53 stably transfected HCT-116 cells into athymic nude mice promoted tumor growth.
|
21394385 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Computational analysis showed that IC53 cDNA is 2538 bp long, encoding 419 amino acids, mapped to chromosome 17q21.31 with 12 exons, ubiquitously expressed in 12 tested normal tissues and 8 tumor cell lines from MTN membranes and vascular endothelial cells by Northern blot and in situ hybridization, and upregulated in the rat models of subacute heart failure and chronic ischemic heart failure by left coronary ligation.
|
12054757 |
2002 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells.
|
22860085 |
2012 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our findings reveal that CDK5RAP3 is widely overexpressed in HCC and that overexpression of CDK5RAP3 promotes HCC metastasis through PAK4 activation.
|
21385901 |
2011 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
LZAP expression was significantly decreased in the tumor tissues and HCC cell lines.
|
22028922 |
2011 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Stable transfection of IC53-2 cDNA into the hepatocellular carcinoma SMMC-7721 cell remarkably stimulates its growth in vitro.
|
12737517 |
2003 |
|
Malignant neoplasm of stomach
|
0.030 |
Biomarker
|
disease |
BEFREE |
Although CDK5RAP3 has been shown to negatively regulate the Wnt/β-catenin signaling pathway in gastric cancer by repressing GSK-3β phosphorylation, its in-depth mechanism has not been determined.
|
29540196 |
2018 |
|
Malignant neoplasm of stomach
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Western Blot was used to detect the expression of CDK5RAP3 and DDRGK1 in gastric cancer and its adjacent tissues and cell lines.
|
30228783 |
2018 |
|
Stomach Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Western Blot was used to detect the expression of CDK5RAP3 and DDRGK1 in gastric cancer and its adjacent tissues and cell lines.
|
30228783 |
2018 |
|
Stomach Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Although CDK5RAP3 has been shown to negatively regulate the Wnt/β-catenin signaling pathway in gastric cancer by repressing GSK-3β phosphorylation, its in-depth mechanism has not been determined.
|
29540196 |
2018 |
|
Malignant neoplasm of stomach
|
0.030 |
Biomarker
|
disease |
BEFREE |
CDK5RAP3 acts as a tumor suppressor in gastric cancer through inhibition of β-catenin signaling.
|
27793695 |
2017 |
|
Stomach Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
CDK5RAP3 acts as a tumor suppressor in gastric cancer through inhibition of β-catenin signaling.
|
27793695 |
2017 |
|
Hepatocarcinogenesis
|
0.030 |
Biomarker
|
disease |
BEFREE |
CDK5 regulatory subunit associated protein 3 (CDK5RAP3) is a novel activator of PAK4 and processes important pro-metastatic function in hepatocarcinogenesis.
|
22860085 |
2012 |
|
Hepatocarcinogenesis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Meanwhile, the function of LZAP in hepatocarcinogenesis was further investigated in cell culture models and mouse models.
|
22028922 |
2011 |
|
Hepatocarcinogenesis
|
0.030 |
Biomarker
|
disease |
BEFREE |
In this article, we report that CDK5RAP3 has an important prometastatic function in hepatocarcinogenesis.
|
21385901 |
2011 |