|
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Possible Role and Therapeutic Target of PDGF-D Signalling in Colorectal Cancer.
|
30836770 |
2019 |
|
Colorectal Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Our study showed that PDGF-D was highly expressed in CRC tissues and was positively associated with the clinicopathological features.
|
28035069 |
2017 |
|
Colorectal Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
In addition, suppression of ZIC5 or PDGFD expression decreased levels of phosphorylated focal adhesion kinase (FAK) and signal transducer and activator of transcription 3 (STAT3) which are associated with PCa and CRC aggressiveness.
|
29024195 |
2017 |
|
Colorectal Carcinoma
|
0.330 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Coronary Arteriosclerosis
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Associations between the CDKN2A/B, ADTRP and PDGFD polymorphisms and the development of coronary atherosclerosis in Japanese patients.
|
24573017 |
2014 |
|
Coronary Artery Disease
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans.
|
23364394 |
2013 |
|
Coronary Arteriosclerosis
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
A case-control study provides evidence of association for a common SNP rs974819 in PDGFD to coronary heart disease and suggests a sex-dependent effect.
|
22704460 |
2012 |
|
Coronary Artery Disease
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
A case-control study provides evidence of association for a common SNP rs974819 in PDGFD to coronary heart disease and suggests a sex-dependent effect.
|
22704460 |
2012 |
|
Coronary Arteriosclerosis
|
0.320 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
|
21378988 |
2011 |
|
Coronary Artery Disease
|
0.320 |
Biomarker
|
disease |
CTD_human |
The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects.
|
21378988 |
2011 |
|
Fibrosis
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
This phenomenon is not limited to TGFβ since other growth factors implicated in fibrosis, such as FGF, EGF and PDGF-B, also regulated PDGF-D and PDGF-C expression.
|
25280005 |
2014 |
|
Lung Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
PDGF-D expression is down-regulated by TGFβ in fibroblasts.
|
25280005 |
2014 |
|
Cirrhosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
PDGF-D expression is down-regulated by TGFβ in fibroblasts.
|
25280005 |
2014 |
|
Chronic Lung Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
PDGF-D expression is down-regulated by TGFβ in fibroblasts.
|
25280005 |
2014 |
|
Glomerulonephritis
|
0.210 |
Biomarker
|
disease |
RGD |
Thus, podocyte-specific overexpression of PDGF-D caused mesangioproliferative disease, glomerulosclerosis, and crescentic glomerulonephritis.
|
21866094 |
2011 |
|
Glomerulonephritis
|
0.210 |
Biomarker
|
disease |
BEFREE |
Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis.
|
16510766 |
2006 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
RGD |
Platelet-derived growth factor involvement in myocardial remodeling following infarction.
|
21767547 |
2011 |
|
Graft Rejection
|
0.200 |
Biomarker
|
phenotype |
RGD |
PDGF-A, -C, and -D but not PDGF-B increase TGF-beta1 and chronic rejection in rat cardiac allografts.
|
19213942 |
2009 |
|
Liver Cirrhosis
|
0.200 |
Biomarker
|
disease |
RGD |
Pro-fibrogenic potential of PDGF-D in liver fibrosis.
|
17397961 |
2007 |
|
Mesangial proliferative glomerulonephritis
|
0.200 |
Therapeutic
|
disease |
RGD |
PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis.
|
17308324 |
2007 |
|
Intimal proliferation
|
0.200 |
Biomarker
|
phenotype |
RGD |
PDGF-D contributes to neointimal hyperplasia in rat model of vessel injury.
|
15752751 |
2005 |
|
Mesangial proliferative glomerulonephritis
|
0.200 |
Biomarker
|
disease |
RGD |
A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis.
|
12937299 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, targeting fibroblasts or PDGF-D-induced signals may represent an effective tool to block tumor-associated lymphangiogenesis and reduce the invasiveness of cholangiocarcinoma.
|
30553841 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Platelet-derived growth factor-D (PDGF-D) can enhance invasion and metastasis in several human malignancies.
|
30652340 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
As a result, we subsequently examined 16 additional cases of primary breast dermatofibrosarcoma protuberans, identifying 2 additional tumors with PDGFD rearrangement.
|
30014607 |
2018 |