TET1, tet methylcytosine dioxygenase 1, 80312

N. diseases: 156; N. variants: 6
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 AlteredExpression disease BEFREE Bioinformatics analyses reveal prevalent hypermethylation of TFPI2 was an early event in tumorigenesis of colorectal caner, and expression of TET1 and TFPI2 was positive correlation in colorectal cancer and normal tissue. 30651599 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 AlteredExpression disease BEFREE Both TET1 expression and global 5-hmC content are significantly reduced in colorectal cancer (CRC), the top leading cause of cancer-related death in the world. 29549908 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 AlteredExpression disease BEFREE Compared to normal tissues, the expression level of TET1 in CRC was significantly lower. 27846738 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 Biomarker disease BEFREE Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has been observed in the colorectal cancer and is crucial for colorectal cancer initiation. 26816554 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 PosttranslationalModification disease BEFREE In the present study, we aimed to clarify the relationship between loss of TET1 and aberrant DNA methylation in CRC. 27977763 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 PosttranslationalModification disease BEFREE TET1 methylation was significantly associated with BRAF mutation but not with hMLH1 methylation in the CIMP-P colorectal cancers. 26063725 2015
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 AlteredExpression disease BEFREE TET1 expression was decreased in half of CRCs, and a large part of them was followed by the loss of 5-hmC. 22320381 2012