TET1, tet methylcytosine dioxygenase 1, 80312

N. diseases: 156; N. variants: 6
Disease: leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia 		0.060 Biomarker disease BEFREE Recent reports suggest TET1 acts as an oncogene in leukemia development. 29402726 2018
CUI: C0023418
Disease: leukemia
leukemia 		0.060 AlteredExpression disease BEFREE TET1 is differentially expressed in many cancers, including leukemia. 29100411 2017
CUI: C0023418
Disease: leukemia
leukemia 		0.060 Biomarker disease BEFREE When examining genes co-expressed with SHB in AML tumors, four other genes ( PAX5, HDAC7, BCORL1, TET1) related to leukemia were identified. 28982308 2017
CUI: C0023418
Disease: leukemia
leukemia 		0.060 Biomarker disease BEFREE Tet2 mutations are drivers in haematological malignancies but Tet1 had an oncogenic role in MLL-rearranged leukaemia, where Tet1 is overexpressed. 25179374 2014
CUI: C0023418
Disease: leukemia
leukemia 		0.060 Biomarker disease BEFREE Collectively, our data delineate an MLL-fusion/Tet1/Hoxa9/Meis1/Pbx3 signaling axis in MLL-rearranged leukemia and highlight TET1 as a potential therapeutic target in treating this presently therapy-resistant disease. 23818607 2013
CUI: C0023418
Disease: leukemia
leukemia 		0.060 AlteredExpression disease BEFREE The MLL-LCX fusion protein lacked a CXXC domain of LCX, but retained an alpha-helical coiled-coil region at the COOH terminus, similar to MLL-SEPTING, MLL-CDCREL1, MLL-AF1p/Eps15, and MLL-AF6, which suggests that these fusion proteins are involved in the pathogenesis of 11q23-associated leukemia through similar mechanisms. 12124344 2002