TET1, tet methylcytosine dioxygenase 1, 80312

N. diseases: 156; N. variants: 6
Disease: Pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain 		0.020 AlteredExpression phenotype BEFREE Overexpression of TET1 in the DRG through microinjection of herpes simplex virus expressing full-length TET1 mRNA into the injured rat DRG significantly alleviated the fifth lumbar spinal nerve ligation (SNL)-induced pain hypersensitivities during the development and maintenance periods, without altering acute pain or locomotor function. 30515739 2019
CUI: C0030193
Disease: Pain
Pain 		0.020 Biomarker phenotype BEFREE Our findings link melatonin/MT2 signaling to Tet1-dependent epigenetic demethylation of nociceptive genes for the first time and suggest melatonin as a promising therapy for the treatment of pain. 28718992 2017