TET1, tet methylcytosine dioxygenase 1, 80312

N. diseases: 156; N. variants: 6
Disease: Colon Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 Biomarker disease BEFREE Tet methylcytosine dioxygenase 1 promotes hypoxic gene induction and cell migration in colon cancer. 30367454 2019
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 AlteredExpression disease BEFREE BRAF<sup>V600E</sup>-mutated CCs and precursors showed a significant downregulation of TET1 and TET2 DNA demethylases. 31842975 2019
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 Biomarker disease BEFREE All of these indicate that TET1 can suppress colon cancer proliferation and the inhibition of the β-catenin pathway is AXIN1 dependent. 30825236 2019
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 Biomarker disease BEFREE Our study demonstrates the existence of a TET1/DUOX2/ROS/EMT axis that could play a role in colon cancer chemo-resistance and the aggressiveness of this cancer. 29715584 2018
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 Biomarker disease BEFREE Loss of TET1 facilitates DLD1 colon cancer cell migration via H3K27me3-mediated down-regulation of E-cadherin. 28513825 2018
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 AlteredExpression disease BEFREE Downregulation of TET1 during colon cancer initiation leads to repression, by DNA methylation, the promoters of the inhibitors of the WNT pathway resulting in a constitutive activation of the WNT pathway. 25362856 2015