|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results detected a significant association between ADAM33 T2, Q1, F + 1 and AA genotype of T + 1 polymorphisms and asthma risk in total population.
|
30791911 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Many asthma susceptibility genes are linked to the immune system or encode enzymes like metalloproteases (e.g., ADAM-33) or serine proteases.
|
27561663 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Strong LD was found among rs678881, rs2280089 and rs2853209, and haplotype GGT was distinctly associated with the risk of asthma in children (OR = 0.28, 95%CI = 0.13-0.57).ADAM33 rs678881 polymorphism is significantly correlated with increased susceptibility to asthma in Chinese Han children.
|
31626088 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The ADAM33 rs528557/S2 and the VEGFA rs833069 SNPs were associated with Thai asthmatics, as well as with other populations worldwide.
|
31586488 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
No association was found between SNPs of ADAM33 with the severity of asthma.
|
31719298 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The studied SNPs of ADAM33 appeared to be non-significant for asthma susceptibility in Northern and Central Punjabi population.
|
31423513 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IFN-γ may participate in airway remodeling in asthma by regulating the expression of the ADAM33 gene.
|
28346792 |
2018 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of ADAM33 gene polymorphisms with asthma in Mongolian and Han groups in Inner Mongolia.
|
30591802 |
2018 |
|
Asthma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
An ovalbumin-induced asthma model in rats was established for investigating the function of the silencing of ADAM33.
|
30450713 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL4Rα and ADAM33 as genetic markers in asthma exacerbations and type-2 inflammatory endotype.
|
28326636 |
2017 |
|
Asthma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Our work confirms that ASO-based gene silencing of ADAM33 is a useful tool for asthma research and therapy.
|
28918018 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In agreement with some other studies in different populations, our results showed no association between frequency of genotype or alleles of both T1 and V4 SNPs in ADAM33 gene and predisposition to asthma in Azerbaijan population of Iran.
|
29149777 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ADAM33 F + 1, T2, and T1 polymorphisms showed significant associations with asthma risks in the overall and Caucasian children, Asian children, and Caucasian and Chinese children, respectively; however, these significant results were unstable in sensitivity analysis.
|
28285393 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our analysis suggests a likely role for ADAM33 and ADAM12 in the development of asthma in Egyptian children.
|
26553447 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The current study aims to evaluate the association of ADAM33 gene polymorphisms with the risk of asthma in the Punjabi population of Pakistan.
|
26666372 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This interaction was notable in that rs910652 is located within 78 kilobases of ADAM33, which is one of the most well studied asthma susceptibility genes.
|
27387956 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between V4 polymorphism in the ADAM33 gene and asthma risk: a meta-analysis.
|
25730038 |
2015 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results provide evidence that the ADAM33 S2 polymorphism is associated with increased susceptibility to pediatric asthma and that the CGG haplotype for the F+1, T1, and S2 polymorphisms is associated with an elevated risk of pediatric asthma in the Han population, whereas the CGC haplotype appears to confer a protective effect.
|
26291893 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The proteins identified in this study were enriched for various mechanisms that are involved in airway hyperresponsiveness, and through the interaction with ADAM33, they may have potential relevance in asthma.
|
25155083 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis.
|
24751681 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ADAM33 gene has been found to be associated with asthma, declined lung function and COPD.
|
24191661 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant association was found between the ADAM33 rs3918396 G>A polymorphism and the risk of asthma among the studied ethnicities (All p>0.05).
|
25068505 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Disintegrin and metalloprotease 33 (ADAM33) have been associated with childhood and adult asthma in many populations.
|
25313536 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The T1 (TC) and V4 (GG) genotypes in the ADAM33 gene were associated with significantly decreased FEV1 levels in patients with asthma.
|
25036518 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This, in turn, will unlock the possibility of ADAM33 as a target for asthma therapy.
|
24817794 |
2014 |