|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Severity of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus: Relationship between Nongenetic Factors and PNPLA3/HSD17B13 Polymorphisms.
|
31694082 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We aimed to assess the prevalence of patatin-like phospholipase domain-containing 3 protein (PNPLA3) gene rs738409 C > G polymorphism in Brazilian individuals with type 2 diabetes and to investigate its association with liver disease severity, diabetic chronic degenerative complications, and metabolic control.
|
31377187 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The PNPLA3 GG genotype interacted with changes in body weight to aggravate liver steatosis but reduced the risk of incident type 2 diabetes in metabolically unhealthy participants.
|
30673802 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
ADPN gene in the human body can be involved in the pathogenesis of T2DM through the NF-κB signaling pathway.
|
29509263 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
As variants in PNPLA3 (I148M) and TM6SF2 (E167K) are associated with nonalcoholic fatty liver disease, we assessed these variants in type 2 diabetes (T2D) patients randomized to receive BIL (n=1822) or GL (n=1270) in three phase 3 trials.
|
29160303 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
|
29632382 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The development of HCC was independently associated with PNPLA3 rs738409 (OR<sub>adjusted</sub> 1.84 [95% CI 1.55-2.18], p = 1.85 × 10<sup>-12</sup>) and TM6SF2 rs58542926 (OR<sub>adjusted</sub> 1.66 [1.30-2.13], p = 5.13 × 10<sup>-05</sup>), using an additive model, and controlling the sex, age, body mass index, and type 2 diabetes mellitus; the risk associated with carriage of MBOAT7 rs641738 (OR<sub>adjusted</sub> 1.04 [0.88-1.24], p = 0.61) was not significant.
|
29535416 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Insulin resistance, the metabolic syndrome or type 2 diabetes and genetic variants of PNPLA3 or TM6SF2 seem to play a role in the pathogenesis of NAFLD.
|
28303724 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
We also found that: (i) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD); (ii) excluding the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (iii) only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and (iv) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (TM6SF2 and PNPLA3) tracked with higher liver fat, higher risk for T2D, and lower risk for CAD, whereas TG-lowering alleles involved in peripheral lipolysis (LPL and ANGPTL4) had no effect on liver fat but decreased risks for both T2D and CAD.
|
29083408 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that the rs738409" genes_norm="80339">I148M/PNPLA3 (rs738409) polymorphism is associated with the presence of pCAD in T2DM patients and with some cardiometabolic parameters.
|
27615511 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This implies that NAFLD is heterogeneous and that "Obese/Metabolic NAFLD" but not NAFLD due to the PNPLA3 or TM6SF2 genetic variants predisposes to type 2 diabetes and cardiovascular disease.
|
27128911 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 51 single-nucleotide polymorphisms (SNPs) previously reported as T2DM or NASH susceptibility loci (PNPLA3) compared between the DM-HCC and DM-non-HCC groups with regard to allele frequencies at each SNP.
|
26337813 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, using two histologically characterized cohorts encompassing steatosis, steatohepatitis, fibrosis and cirrhosis (combined n=1,074), we demonstrate a new association, independent of potential confounding factors (age, BMI, type 2 diabetes mellitus and PNPLA3 rs738409 genotype), with advanced hepatic fibrosis/cirrhosis.
|
24978903 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Multivariate analysis showed susceptibility to advanced fibrotic disease was determined by SOD2 genotype (OR 1.56 (95% CI 1.09-2.25), p=0.014), PNPLA3 genotype (p=0.041), type 2 diabetes mellitus (p=0.009) and histological severity of NASH (p=2.0×10(-16)).
|
21756849 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 I148M was genotyped in a large obese cohort, the SOS study (n = 3,473) and in the Go-DARTS (n = 15,448), a T2D case-control study.
|
22724004 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These findings provide evidence that the PNPLA3 SNP rs738409 contributes to risk for increased liver fat content in African Americans with T2DM, an effect that appears to be independent from serum lipids.
|
21665509 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, we set out to determine whether the PNPLA3 rs738409 polymorphism was associated with liver fibrosis in unselected patients with type 2 diabetes.
|
21745307 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, we set out to determine whether LFC, evaluated using (1)H-MR spectroscopy, was associated with PNPLA3 rs738409 polymorphism in people with type 2 diabetes.
|
20826584 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism (SNP) rs2072907 in the adiponutrin gene (ADPN) was not associated with obesity and type 2 diabetes in Chinese population.
|
19596471 |
2009 |