|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Age-related skeletal muscle loss and patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphisms are both associated with increased liver steatosis and fibrosis in the absence of obesity.
|
31250467 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a sample of 230 overweight/obese children, 105 with NAFLD (hepatic fat fraction ≥5% by magnetic resonance imaging) and 125 without NAFLD, rs738409 in PNPLA3, rs58542926 in TM6SF2, rs1260326 in GCKR, and rs641738 in MBOAT7 were genotyped.
|
31505904 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Children with obesity and PNPLA3 MM genotype show lower eGFR levels compared with other genotypes, with a major effect of this polymorphism in the presence of NAFLD.
|
31184438 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The ORs of fibrosis were significant (P < .05) for patatin like phospholipase domain-containing 3-GG genotype (OR 2.1), parental obesity (OR 2.9), not being breastfed (OR 3.1), vitamin D status (<20 mg/dL) (OR 1.24), and fructose consumption (OR 1.6 per 1 g/day increase), whereas a high SES maternal occupation was inversely associated with fibrosis (OR 0.30).
|
31128886 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to evaluate the association between PNPLA3, key gene of lipid metabolism and the metabolic traits in obesity NAFLD patients with and without prediabetes.
|
31826069 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Two hundred thirty Italian children with obesity were investigated for metabolic parameters and genotyped for PNPLA3, TM6SF2, GCKR, and MBOAT7 gene variants.
|
30710115 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Background The objective of this study was to investigate the association of polymorphisms in four genes, tumor necrosis factor-α (TNFA), patatin-like phospholipase domain containing 3 (PNPLA3), adiponectin (ADIPOQ) and apolipoprotein C3 (APOC3), with obesity and non-alcoholic fatty liver disease (NAFLD) in Asian Indian adolescents.
|
31216264 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here we show that adiposity significantly amplifies the effect of three sequence variants (encoding PNPLA3 p.I148M, TM6SF2 p.E167K, and GCKR p.P446L) associated with nonalcoholic fatty liver disease (NAFLD).
|
28436986 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There was no significant difference in the proportions of patients with rs738409 C>G in PNPLA3, but a significantly greater proportion of patients with lean NAFLD carried rs58542926 C>T in TM6SF2 (4%) than obese or overweight individuals with NAFLD (0.3%; P = .001).
|
28554682 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In multivariate analyses, fibrosis progression was associated with obesity (OR, 1.67; 95% CI, 1.11-2.51) and the PNPLA3 CG/GG genotype (OR, 1.70; 95% CI, 1.13-2.56).
|
26305067 |
2016 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This implies that NAFLD is heterogeneous and that "Obese/Metabolic NAFLD" but not NAFLD due to the PNPLA3 or TM6SF2 genetic variants predisposes to type 2 diabetes and cardiovascular disease.
|
27128911 |
2016 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
PNPLA3 Expression Is Related to Liver Steatosis in Morbidly Obese Women with Non-Alcoholic Fatty Liver Disease.
|
27128907 |
2016 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Liver fat was measured by quantitative ultrasound in 4300 subjects in the Shanghai Changfeng community and analysed for its association with obesity and metabolic factors in individuals with the PNPLA3 CC, CG and GG genotypes.
|
26765961 |
2016 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 rs738409" genes_norm="80339">I148M (rs738409) was genotyped by Taqman assay in 76 overweight/obese individuals [BMI (kg/m(2)) ≥25; mean ± SD age: 59.7 ± 11.4 y; male gender: 70%] with a histologic diagnosis of nonalcoholic fatty liver disease (NAFLD; namely the Milan NAFLD cohort) and in 413 obese men (BMI ≥30; mean ± SD age: 57.1 ± 4.9 y) from the α-Tocopherol, β-Carotene Cancer Prevention (ATBC) Study.
|
26136587 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two hundred and eighty-eight overweight/obese and 209 normal weight participants of the STYJOBS/EDECTA cohort (NCT00482924) were analysed for PNPLA3 genotypes.
|
25939720 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Compared to recipients with only the PNPLA3 GG allele or obesity (defined as body mass index > 25 kg/m(2)), steatosis was highly prevalent (71.4%) in PNPLA3 GG carriers with obesity.
|
26379412 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide analysis of hepatic lipid content in extreme obesity.
|
25246029 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A total of 372 subjects were divided into groups based on PNPLA3 genotype or obesity.
|
24009255 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Stratifying the patients with the GPR120 270H variant on the basis of their PNPLA3 polymorphism, we demonstrated a significant interaction effect on ALT levels (P = 0.00001), suggesting a driving effect of the PNPLA3 148M allele on liver injury in children with obesity carrying this variant.
|
25250621 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the interactions of PNPLA3 rs738409 with a broad panel of metabolic and histologic characteristics of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH) in patients with medically complicated obesity.
|
23418085 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The I148M PNPLA3 variant is strongly associated with elevated ALT levels in normal weight and overweight/obese Mexican children.
|
23510779 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, PNPLA-3 non-CC genotype is associated with posttransplant obesity but not independently with diabetes/IFG.
|
23859071 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fasting serum insulin was higher in the obese than the non-obese group (76 ± 6 vs 47 ± 6 pmol/l, p < 0.001), but similar in PNPLA3-148MM and PNPLA3-148II (60 ± 8 vs 62 ± 5 pmol/l, NS).
|
23334462 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to determine whether increased adipocyte size is associated with increased liver fat content due to nonalcoholic fatty liver disease (NAFLD) in humans independent of obesity, fat distribution and genetic variation in the patatin-like phospholipase domain-containing 3 gene (PNPLA3; adiponutrin) at rs738409.
|
23913731 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Non-alcoholic fatty liver disease (NAFLD) is commonly diagnosed in patients with obesity and type 2 diabetes mellitus (T2DM), and has been associated with the single nucleotide polymorphism (SNP) rs738409 in the PNPLA3 gene.
|
21665509 |
2011 |