|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Metabolic syndrome (MetS) and genetic polymorphisms PNPLA3 rs738409, TM6SF2 rs58542926 and MBOAT7 rs641738 are known inductors of non-alcoholic fatty liver disease (NAFLD).
|
31851849 |
2019 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The carriers of the PNPLA3 I148M variant also have a 3 times higher risk for the presence of metabolic syndrome (OR 2.939, 95% CI: 1.590-5.434, p=0.001) and a 2.1-fold higher risk for the presence of insulin resistance (OR 2.127, 95% CI: 1.078-4.194, p=0.029).
|
31826069 |
2019 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NAFLD associated with certain genetic factors such as the PNPLA3 G allele variant is not accompanied by insulin resistance and MS. Lifestyle modification, including diet and physical activity targeting visceral adiposity, remains the standard of care for patients with NAFLD and MS.
|
29128053 |
2018 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to evaluate the role of PNPLA3 rs738409 in the development of MS and HS in CD patients after starting GFD.
|
30189691 |
2018 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Insulin resistance, the metabolic syndrome or type 2 diabetes and genetic variants of PNPLA3 or TM6SF2 seem to play a role in the pathogenesis of NAFLD.
|
28303724 |
2017 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aim of the study was to evaluate the role of hepatic copper content, PNPLA3 in NAFLD patients with and without metabolic syndrome (MetS).
|
27908400 |
2017 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Such potential examples of genotypes that are associated with a dissociation between liver disease and metabolic syndrome are patatin-like phospholipase domain-containing protein-3 (PNPLA3) (I148M) and transmembrane 6 superfamily member 2 protein (TM6SF2) (E167K) genotypes.
|
26978356 |
2016 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The I148M variant in PNPLA3 and the E167K variant in TM6SF2 are both associated with increased liver fat content, but not features of the metabolic/insulin resistance syndrome.
|
27432073 |
2016 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
First, we analyze the impact of demographic and ethnic characteristics of the PNPLA3 I148M variant and the presence of metabolic syndrome on the association between PNPLA3 I148M and NAFLD.
|
25624712 |
2015 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PNPLA3 rs738409 polymorphism is associated already in youths with increased ALT, and is more frequent in obese with MetS of all ages.
|
25939720 |
2015 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Modern noninvasive liver graft assessment frequently detects hepatic steatosis, which is associated with graft fibrosis, components of the metabolic syndrome and recipient PNPLA3 rs738409 genotype, especially in ALC patients.
|
25429378 |
2015 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Age and HOMA-IR were positive independent predictors of metabolic syndrome, while a negative independent association was found between metabolic syndrome and the homozygotes PNPLA3 I148M variant.
|
24947770 |
2014 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The G allele in PNPLA3 rs738409 increases the risk of NAFLD in the general population, especially in subjects without metabolic syndrome, independent of dietary pattern and metabolic factors.
|
24417250 |
2014 |
|
Metabolic Syndrome X
|
0.100 |
Biomarker
|
disease |
BEFREE |
Steatosis in PNPLA3-associated NAFLD is not accompanied by features of metabolic syndrome.
|
24731669 |
2014 |
|
Metabolic Syndrome X
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation at PNPLA3 confers a markedly increased risk of increasingly severe histological features of NAFLD, without a strong effect on metabolic syndrome component traits.
|
20648472 |
2010 |