|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In patients with nonalcoholic steatohepatitis (NASH), PNPLA3 GG compared to CC was associated with higher AST levels [38.4±25.3 versus 36.7±40.1IU/L, p=0.0395)] and with the presence of liver fibrosis (≥F2 fibrosis, p=0.0272).
|
31054980 |
2020 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The progression of NAFLD, including nonalcoholic steatohepatitis (NASH), has a strong genetic component, and the most robust contributor is the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 encoding the 148M protein sequence variant.
|
30772256 |
2019 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers.
|
29385134 |
2018 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The patatin-like phospholipase domain-containing 3 (PNPLA3) gene has been associated with the development of alcoholic and nonalcoholic steatohepatitis.
|
30218427 |
2018 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-α.
|
28264426 |
2017 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain containing 3 gene (PNPLA3, rs738409) has been associated with fibrosis and development of hepatocellular carcinoma (HCC) in patients with nonalcoholic steatohepatitis, although its association with outcomes in patients with hepatitis C virus (HCV) infection is less clear.
|
26305067 |
2016 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We used real-time polymerase chain reaction (PCR) analysis to analyze the hepatic expression of PNPLA3 and lipid metabolism-related genes in 55 morbidly obese subjects with normal liver histology (NL, n = 18), simple steatosis (SS, n = 20), and non-alcoholic steatohepatitis (NASH, n = 17).
|
27128907 |
2016 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
PNPLA3 genotype increases susceptibility of nonalcoholic steatohepatitis among obese patients with nonalcoholic fatty liver disease.
|
25240529 |
2016 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.
|
27180240 |
2016 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interactions of a PPARGC1A Variant and a PNPLA3 Variant Affect Nonalcoholic Steatohepatitis in Severely Obese Taiwanese Patients.
|
27015186 |
2016 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism (SNP) of the PNPLA3-gene is associated with development of non-alcoholic steatohepatitis and a worse outcome in alcoholic liver disease.
|
26599080 |
2015 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In patients with both CHB and NAFLD, these genotypes of PNPLA3 polymorphisms were associated with increased susceptibility to nonalcoholic steatohepatitis (NASH) (NAFLD activity score ≥ 3; P = 0.01-0.03) and liver fibrosis (> 1 Metavir grading; P = 0.01-0.04).
|
26229402 |
2015 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The patatin-like phospholipase domain-containing 3 gene (PNPLA3) has been associated with liver steatosis and disease progression in nonalcoholic steatohepatitis and chronic hepatitis C.
|
25986529 |
2015 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conducted a meta-analysis to assess the association between patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) and its subtypes simple steatosis(SS) and nonalcoholic steatohepatitis (NASH).
|
25791171 |
2015 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
PNPLA3 is associated with an increased risk of advanced fibrosis among patients with a variety of liver diseases and is an independent risk factor for HCC among patients with nonalcoholic steatohepatitis or alcohol-related cirrhosis.
|
24445574 |
2014 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease.
|
24531328 |
2014 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in the PNPLA3 gene are associated with nonalcoholic steatohepatitis.
|
24831885 |
2014 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The percentage of patients with non-alcoholic steatohepatitis (NASH) was significantly different according to the PNPLA3 variant.
|
23512881 |
2013 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, the common variant p.I148M of the enzyme adiponutrin (PNPLA3) has emerged as a major genetic determinant of hepatic steatosis and nonalcoholic steatohepatitis as well as its pathobiological sequelae fibrosis, cirrhosis, and hepatocellular cancer.
|
24222094 |
2013 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the interactions of PNPLA3 rs738409 with a broad panel of metabolic and histologic characteristics of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH) in patients with medically complicated obesity.
|
23418085 |
2013 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In patients with NAFLD, adiponutrin rs738409 C-->G genotype, encoding for rs738409" genes_norm="80339">I148M, is associated with the severity of steatosis and fibrosis and the presence of nonalcoholic steatohepatitis.
|
20373368 |
2010 |
|
Nonalcoholic Steatohepatitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.
|
18820647 |
2008 |