Cardiomyopathy, Dilated
|
0.370 |
GeneticVariation
|
group |
BEFREE |
Muscle LIM protein (MLP, CSRP3) is a key regulator of striated muscle function, and its mutations can lead to both hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in patients.
|
31406109 |
2019 |
Cardiomyopathy, Dilated
|
0.370 |
Biomarker
|
group |
BEFREE |
MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy.
|
27353086 |
2016 |
Cardiomyopathy, Dilated
|
0.370 |
Biomarker
|
group |
MGD |
Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure.
|
18713466 |
2008 |
Cardiomyopathy, Dilated
|
0.370 |
GeneticVariation
|
group |
BEFREE |
Previous studies have shown an association between CSRP3 missense mutations and either dilated cardiomyopathy (DCM) or HCM, but all these studies were unable to provide comprehensive genetic evidence for a causative role of CSRP3 mutations.
|
18505755 |
2008 |
Cardiomyopathy, Dilated
|
0.370 |
Biomarker
|
group |
BEFREE |
An MLP-deficient mouse has been described; these mice develop dilated cardiomyopathy and heart failure.
|
14567970 |
2004 |
Cardiomyopathy, Dilated
|
0.370 |
Biomarker
|
group |
MGD |
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
|
14966518 |
2004 |
Cardiomyopathy, Dilated
|
0.370 |
Biomarker
|
group |
BEFREE |
MLP-knockout mice develop a marked cardiac hypertrophy reaction and dilated cardiomyopathy (DCM).
|
12642359 |
2003 |
Cardiomyopathy, Dilated
|
0.370 |
GeneticVariation
|
group |
LHGDN |
Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy.
|
12642359 |
2003 |
Cardiomyopathy, Dilated
|
0.370 |
Biomarker
|
group |
BEFREE |
Mice with a disruption of the MLP gene resemble the morphological and clinical picture of dilated cardiomyopathy and heart failure in humans.
|
10851202 |
2000 |
Cardiomyopathy, Dilated
|
0.370 |
Biomarker
|
group |
MGD |
Cellular and functional defects in a mouse model of heart failure.
|
11087268 |
2000 |
Cardiomyopathy, Dilated
|
0.370 |
Biomarker
|
group |
BEFREE |
In vivo analysis revealed that MLP-deficient mice reproduce the morphological and clinical picture of dilated cardiomyopathy and heart failure in humans, providing the first model for this condition in a genetically manipulatable organism.
|
9039266 |
1997 |
Cardiomyopathy, Dilated
|
0.370 |
Biomarker
|
group |
MGD |
MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure.
|
9039266 |
1997 |
Cardiomyopathy, Dilated
|
0.370 |
CausalMutation
|
group |
CLINVAR |
|
|
|
Cardiomyopathy, Dilated
|
0.370 |
GeneticVariation
|
group |
CLINVAR |
|
|
|
Cardiomyopathy, Dilated
|
0.370 |
Biomarker
|
group |
HPO |
|
|
|