Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice in sepsis were administered CLP surgery.
|
30690081 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cultured human pulmonary epithelial cell line A549 was challenged with LPS to induce cell injury, and CLP mouse model was generated to mimic clinical condition of systemic sepsis.
|
30918470 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sepsis and AKI were induced 12 h after CLP.
|
31223614 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, PRAK dysfunction could lead to impaired NET-mediated antibacterial activity and shorten the survival of mice with CLP-induced sepsis.
|
31231384 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, the decreased levels of FRAP and GSH induced by sepsis were remarkably (p < 0.05) risen by the administration of DDWs and ML in comparison to the CLP group.
|
30961427 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lactobacillus rhamnosus GG Ameliorates Liver Injury and Hypoxic Hepatitis in Rat Model of CLP-Induced Sepsis.
|
31049763 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of matrix metalloproteinase 8 and tumor necrosis factor receptor 1 might have therapeutic potential to treat sepsis and proof-of-principle was provided as therapeutics that inhibit both tumor necrosis factor receptor 1 and matrix metalloproteinase 8 are effective in CLP.
|
29095202 |
2018 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, survival of wild type mice subjected to the lethal CLP sepsis was not improved with broad-spectrum antibiotics, whereas the survival of NFATc3 deficient mice was improved to 40-60% when treated with imipenem.
|
29535830 |
2018 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggested that the cecal ligation combined with puncture drainage model of sepsis is more stable than that of the simple cecal ligation and puncture model of sepsis in the rat, which resolved the problem of puncture wrapped in the traditional CLP model of sepsis in rat.
|
29937001 |
2018 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
By combining phenotypic analysis of exhaustion markers with functional analysis of cytokine production, we found that PD-1+ CD4+ cells in cancer hosts failed to make any cytokines following CLP, while the 2B4+ PD-1lo cells in cancer mice secreted increased TNF during sepsis.
|
29338031 |
2018 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymicrobial sepsis (after cecal ligation and puncture, CLP) causes robust complement activation with release of C5a.
|
29914696 |
2018 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In mice with cecal ligation and puncture-induced sepsis, treatment with GRK2 inhibitor reduced high levels of oxidative and nitrosative stress in the mice brains, where GRK2 expression was up-regulated, alleviated neurohistological damage observed in cerebral cortex sections, and conferred a significant survival advantage to CLP mice.
|
29500815 |
2018 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using CLP sepsis model, we observed that sepsis induces apoptosis of circulating memory CD8 T-cells (TCIRCM) and diminishes their effector functions, leading to impaired CD8 T-cell mediated protection to systemic pathogen re-infection.
|
28910403 |
2017 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
26 male Wistar rats were assigned to either a sham group (control, <i>N</i> = 6) or sepsis group (<i>N</i> = 20; cecal ligature and puncture model, 24 and 48 hours after CLP).
|
28246552 |
2017 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lower ARE (153.24 vs. 264.32U/L; p<0.001), lower CLP (80.58 vs. 97.98U/L; p=0.032), lower MPO (91.24 vs. 116.55U/L; p=0.023), and higher CAT levels (256.5 vs.145.5kU/L; p=0.003) were determined in the sepsis group as compared to the control group.
|
28167245 |
2017 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found BMDN-treated with f-MLP or that were exposed to sepsis by CLP had increased Rac1 signaling, whereas the cells pretreated with MSP68 had significantly reduced Rac1 activation (P < 0.05).
|
27993196 |
2017 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, sepsis results in profound and persistent changes in the function of myeloid cells up to 28 days after CLP demonstrating the persistence of the new acquired immunological features long after resolution of the sepsis.
|
28715505 |
2017 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the sepsis CLP mouse model, CTLs are activated toward alloantigenic target cells.
|
25559266 |
2015 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stk38-deficient mice are also more susceptible to CLP-induced sepsis than control mice.
|
25981615 |
2015 |