FGF23, fibroblast growth factor 23, 8074

N. diseases: 305; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE Crosstalk between fibroblast growth factor 23, iron, erythropoietin, and inflammation in kidney disease. 31145704 2019
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE FGF23 has also been shown to independently predict progression of renal disease, however, whether FGF23 and FGFR4 also contribute to CKD remains unknown. 31575945 2019
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE Objective Non-alcoholic fatty liver disease, steatohepatitis and nephropathy are considered among the most important complications of diabetes mellitus (DM), which recently increased due to increased frequency of DM and the prolonged life span of diabetic patients The aim of the present study was to reveal the possible effect of hesperidin (HP) on alpha-klotho (α-KL)/ fibroblast growth factor-23 (FGF-23) pathway in rats with diabetes induced by streptozotocin (STZ). 30551370 2019
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE αKlotho-FGF23 interactions and their role in kidney disease: a molecular insight. 31350618 2019
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 AlteredExpression group BEFREE Patients with kidney disease have increased circulating levels of FGF23 and in other patient populations and in healthy individuals, FGF23 levels also rise following an increase in dietary phosphate intake. 30514976 2019
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 AlteredExpression group BEFREE The aim of current study is investigation of theimpact of serum FGF23 levels on blood pressure of patients withend-stage renal disease (ESRD) undergoing hemodialysis. 31422393 2019
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE In addition, a higher concentration of FGF-23 reduced the odds of early nephropathy in patients with T2DM. 30718148 2018
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk. 29735309 2018
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE This may explain, or at least contribute to, the decrease in Klotho and promote fibroblast growth factor 23 resistance in early CKD categories, as observed in preclinical and clinical proteinuric kidney disease. 29425318 2018
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE Previous studies showed that circulating fibroblast growth factor-23 (FGF23) is a new biomarker linked to cardiovascular and kidney diseases. 27427468 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 AlteredExpression group BEFREE Circulating levels of fibroblast growth factor 23 (FGF23) increase during the early stages of kidney disease, but the underlying mechanism remains incompletely characterized. 27535551 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE Fibroblast growth factor 23 (FGF23) is a novel biomarker positively associated with left ventricular hypertrophy in adults with and without kidney disease. 28456498 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE Fibroblast Growth Factor 23 and Kidney Disease Progression in Autosomal Dominant Polycystic Kidney Disease. 28705885 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 AlteredExpression group BEFREE Advanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression. 29147074 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 AlteredExpression group BEFREE However, high FGF23 levels become pathological as kidney disease progresses and are associated with an increased risk of CKD progression, cardiovascular events, and death. 27582104 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 AlteredExpression group BEFREE Circulating FGF23 levels rise precipitously in patients with kidney disease and portend worse renal and cardiovascular outcomes. 28919046 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group BEFREE FGF-23 was slightly elevated, perhaps from kidney disease. 27005479 2016
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 AlteredExpression group BEFREE Through independent and combined effects on renal phosphorus and vitamin D metabolism, alterations in FGF23 and Klotho expression are essential for maintaining mineral homeostasis in kidney disease. 23611556 2013
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 AlteredExpression group BEFREE We investigated the association between FGF23 serum levels and kidney disease progression, as well as the phenotypic features of CKD-MBD in a Col4a3 null mouse model of human autosomal-recessive Alport syndrome. 22031097 2012
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 AlteredExpression group LHGDN Regulation of fibroblast growth factor-23 in chronic kidney disease. 17567652 2007
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.100 Biomarker group LHGDN Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers. 14633152 2003