|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
FGF23 gene expression increases during iron deficiency.
|
31652009 |
2020 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Iron deficiency increases FGF23 mRNA expression and recent evidence suggests that the recurrent, late-onset, or waxing-waning hypophosphatemic phenotype may be linked to synchronous variations in iron status.
|
31834957 |
2020 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we aimed to determine the associations between iron deficiency and higher EPO levels with mortality, and the potential mediating role of FGF23, in a cohort of community-dwelling subjects.
|
31170159 |
2019 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Earlier studies adjusted for CKD-mineral bone disease (CKD-MBD) regulators of FGF23 rather than for recently discovered non-CKD-MBD regulators, among which iron deficiency and heart failure are of particular importance.
|
30808827 |
2019 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that ferric citrate hydrate, an iron-based phosphate binder, will decrease serum FGF23 levels in patients with non-dialysis-dependent CKD with normophosphatemia and iron deficiency.
|
29181658 |
2018 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
FGF23 formation and/or release are stimulated by 1,25(OH)2D3, phosphate excess, Ca2+, PTH, leptin, catecholamines, mineralocorticoids, volume depletion, lithium, high fat diet, iron deficiency, TNFα and TGFß2.
|
30504710 |
2018 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, iron deficiency and hypoxia have been suggested as additional regulators of FGF23 and a role of erythropoietin (EPO) was shown.
|
29961920 |
2018 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Fibroblast growth factor 23 (FGF23) production is upregulated by iron deficiency and hypoxia.
|
28877877 |
2018 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
We hypothesized that in RTRs, the relationship between ID and mortality is mediated by FGF23.
|
28774998 |
2017 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to determine whether oral ferrous iron (Fe<sup>2+</sup> ) reduces the serum FGF23 levels of iron-deficient maintenance haemodialysis (MHD) patients in the same way as oral ferric iron (Fe<sup>3+</sup> ) METHODS: Thirty-one MHD patients with iron deficiency were enrolled in this prospective study.
|
27558654 |
2017 |
|
Iron deficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Novel Faces of Fibroblast Growth Factor 23 (FGF23): Iron Deficiency, Inflammation, Insulin Resistance, Left Ventricular Hypertrophy, Proteinuria and Acute Kidney Injury.
|
27826644 |
2017 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dysregulation of intracellular FGF23-processing mechanisms may be related to iron deficiency per se rather than iron repletion with iron polymaltose.
|
27848940 |
2017 |
|
Iron deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Beside its role in phosphate homeostasis, iron deficiency and anemia are associated with increased FGF23 plasma levels.
|
29073196 |
2017 |
|
Iron deficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We previously demonstrated that the combination of iron deficiency and a knock-in R176Q FGF23 mutation in mature mice induced FGF23 expression and hypophosphatemia that paralleled the late-onset ADHR phenotype.
|
23873717 |
2014 |
|
Iron deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unlike osteocytes in ADHR, normal osteocytes couple increased FGF23 production with commensurately increased FGF23 cleavage to ensure that normal phosphate homeostasis is maintained in the event of iron deficiency.
|
24867675 |
2014 |