FGF23, fibroblast growth factor 23, 8074

N. diseases: 305; N. variants: 19
Disease: Hypervitaminosis D ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1442839
Disease: Hypervitaminosis D
Hypervitaminosis D 		0.040 Biomarker disease BEFREE Genetic deletion of Fgf-23 in mice (Fgf-23(-/-)) results in hypervitaminosis D, abnormal mineral metabolism, and reduced lymphatic organ size. 24509850 2014
CUI: C1442839
Disease: Hypervitaminosis D
Hypervitaminosis D 		0.040 Biomarker disease BEFREE Fibroblast growth factor-23 (FGF23) is a circulating hormone that acts to correct hyperphosphatemic states by inhibiting renal phosphate reabsorption and to prevent hypervitaminosis D by feedback repressing 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) biosynthesis. 23263654 2013
CUI: C1442839
Disease: Hypervitaminosis D
Hypervitaminosis D 		0.040 AlteredExpression disease BEFREE With regard to their serum biochemistry, double mutants reversed the severe hyperphosphataemia, hypercalcaemia, and hypervitaminosis D found in Fgf-23(-/-) littermates; rather, double mutants show hypophosphataemia and normal serum 1,25-dihydroxyvitamin D(3) levels similar to pure FGF-23 Tg mice. 18729070 2008
CUI: C1442839
Disease: Hypervitaminosis D
Hypervitaminosis D 		0.040 Biomarker disease BEFREE Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. 16731043 2006